(Q28344650)

English

Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells

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Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells (English)

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author name string

C E Verhagen

1

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de Boer T

2

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H H Smits

3

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F A Verreck

4

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E A Wierenga

5

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M Kurimoto

6

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D A Lammas

7

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D S Kumararatne

8

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O Sanal

9

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F P Kroon

10

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van Dissel JT

11

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F Sinigaglia

12

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T H Ottenhoff

13

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language of work or name

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publication date

21 August 2000

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Journal of Experimental Medicine

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192

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4

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517-28

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Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor β1 Subunit

1 reference

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20 March 2017

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection

1 reference

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20 March 2017

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

1 reference

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20 March 2017

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

1 reference

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20 March 2017

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

20 March 2017

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

20 March 2017

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

1 reference

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20 March 2017

Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production

1 reference

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20 March 2017

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

1 reference

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20 March 2017

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

20 March 2017

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

20 March 2017

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

20 March 2017

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

7 April 2017

Functional diversity of helper T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

7 April 2017

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

7 April 2017

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

7 April 2017

Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

29 September 2017

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

29 September 2017

Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

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Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

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Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

29 September 2017

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

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Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements

1 reference

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Selection of a human T helper type 1-like T cell subset by mycobacteria

1 reference

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Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production

1 reference

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29 September 2017

Functional subsets of allergen-reactive human CD4+ T cells

1 reference

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IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection

1 reference

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Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria

1 reference

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Mice lacking IL-12 develop polarized Th1 cells during viral infection

1 reference

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Structural and Functional Aspects of the IL-12 Receptor Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

2 June 2018

IL-12-deficient mice are defective but not devoid of type 1 cytokine responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

2 June 2018

Mycobacterium leprae-specific protein antigens defined by cloned human helper T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

2 June 2018

IL-4 directs the development of Th2-like helper effectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193232

2 June 2018

Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo

1 reference

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27 November 2018

The role of Stat4 in species-specific regulation of Th cell development by type I IFNs

1 reference

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27 November 2018

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells

1 reference

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Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1 reference

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27 November 2018

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

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based on heuristic

inferred from PubMed ID database lookup

Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of IL-12 signaling in human allergen-specific Th2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alloantigen-reactive Th1 development in IL-12-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of integrin alpha6/beta1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10952721

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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