(Q28361778)

6 July 2017

title

The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites (English)

1 reference

6 July 2017

Purba HS

1

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6 July 2017

Maggs JL

2

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6 July 2017

Orme ML

3

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6 July 2017

Back DJ

4

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6 July 2017

Park BK

5

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6 July 2017

language of work or name

English

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publication date

1 April 1987

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British Journal of Clinical Pharmacology

6 July 2017

published in

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6 July 2017

volume

23

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6 July 2017

issue

4

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6 July 2017

page(s)

447-453

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Protein measurement with the Folin phenol reagent

6 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Effects of Insecticide Synergists on Microsomal Oxidation of Estradiol and Ethynylestradiol and on Microsomal Drug Metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Metabolic activation and drug toxicity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

2-Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Metabolism of stilbene estrogens and steroidal estrogens in relation to carcinogenicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

29 September 2017

Human cytochromes P-450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

29 September 2017

The catechol estrogens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

The urinary metabolites of 17α-ethynylestradiol-9α,11-3H in women chromatographic profiling and identification of ethynyl and non-ethynyl compounds

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Drug protein conjugates--III. Inhibition of the irreversible binding of ethinylestradiol to rat liver microsomal protein by mixed-function oxidase inhibitors, ascorbic acid and thiols

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

In vitro effects of quinoline derivatives on cytochrome P-450 and aminopyrine N-demethylase activity in rat hepatic microsomes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Metabolism of progesterone and estradiol by microsomes and purified cytochrome P-450 RLM3 and RLM5

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Excretion of steroid hormones in adults. C19 and C21 steroids in faeces from pregnant women

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Irreversible binding of ethynyl-estradiol metabolites to protein and nucleic acids as catalyzed by rat liver microsomes and mushroom tyrosinase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Attempts to phenotype human liver samples in vitro for debrisoquine 4-hydroxylase activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Inhibition of estrogen 2-hydroxylase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

The presence of dl-, d- and l-norgestrel and their metabolites in the plasma of women

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386094

Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites

27 November 2018

1 reference

12 December 2020

Structure-activity relationships in the effects of 1-alkylimidazoles on microsomal oxidation in vitro and in vivo

1 reference

12 December 2020

Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates

1 reference

12 December 2020

Cytochrome P-450 monooxygenase activities in human and rat liver microsomes

1 reference

12 December 2020

The biotransformation of 17 alpha-ethynyl[3H]estradiol in the rat: irreversible binding and biliary metabolites

1 reference

12 December 2020

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1 reference

12 December 2020

Interindividual variations in drug disposition. Clinical implications and methods of investigation

1 reference

12 December 2020

The biliary and urinary metabolites of [3H]17 alpha-ethynylestradiol in women

1 reference

12 December 2020

Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro

1 reference

12 December 2020

Variation in hepatic microsomal cytochrome P-450 1 concentration among untreated rabbits alters the efficiency of estradiol hydroxylation

1 reference

12 December 2020

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction

1 reference

12 December 2020

Estrogen 1,2-epoxides or estrogen quinones/semiquinones

1 reference

12 December 2020

Mephenytoin hydroxylase activity in human liver: inhibition by steroids

1 reference

12 December 2020

10.1111/J.1365-2125.1987.TB03074.X

Identifiers

DOI

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6 July 2017

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6 July 2017

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