(Q28363024)

English

Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis

scientific article

In more languages

Statements

scholarly article

0 references

Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis (English)

0 references

author name string

J K Callaway

1

0 references

P M Beart

2

0 references

B Jarrott

3

0 references

S F Giardina

4

0 references

language of work or name

0 references

publication date

April 2001

0 references

British Journal of Pharmacology

0 references

132

0 references

8

0 references

1691-8

0 references

Pathobiology of ischaemic stroke: an integrated view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

20 March 2017

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

20 March 2017

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

7 April 2017

Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

The regulation of reactive oxygen species production during programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Apoptosis in focal cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Effect of 21-aminosteroid lipid peroxidation inhibitor, U74006F, in the rat middle cerebral artery occlusion model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Neuroprotective profile of lifarizine (RS‐87476) in rat cerebrocortical neurones in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

29 September 2017

Terfenadine prevents NMDA receptor-dependent and -independent toxicity following sodium channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Apoptosis, excitotoxicity, and neuropathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation in neuronal cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Activation of voltage-dependent sodium channels in cultured cerebellar poffule cells induces neurotoxicity that is not mediated by glutamate release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

N-acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

2 June 2018

Recruitment of several neuroprotective pathways after permanent focal ischemia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

The importance of voltage-dependent sodium channels in cerebral ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

A reliable procedure for comparison of antioxidants in rat brain homogenates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Hydroxyl radical generation after the third hour following ischemia contributes to brain damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Long-term beneficial effects of BW619C89 on neurological deficit, cognitive deficit and brain damage after middle cerebral artery occlusion in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Programmed cell death and Bcl-2 protection in very low oxygen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572735

27 November 2018

Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and Free Radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen intermediates as mediators of programmed cell death in plants and animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole Inhibits Apoptosis by Preventing Caspase Activation Following Mitochondrial Depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed treatment with AM-36, a novel neuroprotective agent, reduces neuronal damage after endothelin-1-induced middle cerebral artery occlusion in conscious rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by LY341122, a novel inhibitor of lipid peroxidation, against focal ischemic brain damage in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous nuclease. Properties and effects on transcribed genes in chromatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11309240

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704018

0 references

PMC publication ID

0 references

PubMed publication ID

0 references

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28363024&oldid=1391323623"