(Q28364133)

English

Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication

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scholarly article

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Inhibitory effects of small-molecule CCR5 antagonists on human immunodeficiency virus type 1 envelope-mediated membrane fusion and viral replication (English)

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infectious disease

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author name string

K Takashima

1

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H Miyake

2

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R A Furuta

3

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J I Fujisawa

4

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Y Iizawa

5

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N Kanzaki

6

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M Shiraishi

7

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K Okonogi

8

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M Baba

9

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language of work or name

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publication date

December 2001

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Antimicrobial Agents and Chemotherapy

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45

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12

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3538-43

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

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20 March 2017

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

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20 March 2017

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1 reference

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20 March 2017

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

1 reference

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20 March 2017

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

1 reference

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20 March 2017

Identification of a major co-receptor for primary isolates of HIV-1

1 reference

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20 March 2017

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1 reference

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20 March 2017

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

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20 March 2017

Capture of an early fusion-active conformation of HIV-1 gp41

1 reference

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20 March 2017

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

1 reference

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20 March 2017

Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection

1 reference

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20 March 2017

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

1 reference

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20 March 2017

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1 reference

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7 April 2017

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1 reference

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7 April 2017

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 reference

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7 April 2017

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

1 reference

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7 April 2017

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

1 reference

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7 April 2017

Establishment of a CCR5-expressing T-lymphoblastoid cell line highly susceptible to R5 HIV type 1.

1 reference

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29 September 2017

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

1 reference

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29 September 2017

Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel

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29 September 2017

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

1 reference

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29 September 2017

Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry

1 reference

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29 September 2017

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

1 reference

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29 September 2017

The second extracellular loop of CCR5 is the major determinant of ligand specificity.

1 reference

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29 September 2017

CC chemokine receptor 5-mediated signaling and HIV-1 Co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion

1 reference

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29 September 2017

HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

1 reference

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29 September 2017

Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation.

1 reference

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29 September 2017

Identifiers

10.1128/AAC.45.12.3538-3543.2001

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release_5ru4oacnarb23ptn4jzv23uw4m

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PubMed publication ID

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