(Q28369193)

English

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

apoptotic process

1 reference

based on heuristic

inferred from title

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

J. Silvio Gutkind

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

author name string

Patel V

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Senderowicz AM

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Igishi T

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Raffeld M

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Quintanilla-Martinez L

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Ensley JF

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Sausville EA

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

language of work or name

0 references

publication date

1 November 1998

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Journal of Clinical Investigation

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

102

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1674-1681

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

20 March 2017

Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

20 March 2017

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

20 March 2017

Cell cycle checkpoints: preventing an identity crisis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

7 April 2017

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

7 April 2017

Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

29 September 2017

An information-intensive approach to the molecular pharmacology of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

29 September 2017

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

29 September 2017

Cell cycle analysis of apoptosis using flow cytometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

29 September 2017

Molecular targets in the National Cancer Institute drug screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

29 September 2017

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Altered expression and activity of G1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Chemical inhibitors of cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Growth inhibitory concentrations of EGF induce p21 (WAF1/Cip1) and alter cell cycle control in squamous carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Use of meta-analysis to evaluate tolonium chloride in oral cancer screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Alternating cisplatinum and VAC ineffective in end stage squamous cell carcinoma of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

2 June 2018

Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=509115

27 November 2018

Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of p53 gene mutation after irradiation is associated with increased aggressiveness in recurring head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computerized patient record systems: a survey of 28 vendors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant chemotherapy in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathologic comparison between human oral squamous cell carcinomas and their xenografts in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent cancer trends in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI3661

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9802881%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28369193&oldid=1945829034"