(Q28369605)

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Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy

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Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy (English)

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author name string

K Kitani

1

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S Kanai

2

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G O Ivy

3

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M C Carrillo

4

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language of work or name

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publication date

November 1999

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Mechanisms of Ageing and Development

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111

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2-3

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211-21

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L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males.

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Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain ofDrosophila

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Symptomatic and neuroprotective properties of the aliphatic propargylamines

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(-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats

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(-)Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in hippocampus: the sex and age-related differences in the optimal dose in the rat

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Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats

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Age-related changes in antioxidant enzyme activities are region and organ, as well as sex, selective in the rat

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The ability of (-)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective

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The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats

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Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain.

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Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

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Prolongation of the normal life span by radiation protection chemicals

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Free-radical theory of aging. Increasing the functional life span

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Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence

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Ursodeoxycholic acid reduces the systemic toxicity of 1,2-dichloro,4-nitrobenzene by stimulating hepatic glutathione S-transferase in mice

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Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension

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Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models

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The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl

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Aging and resistance to oxidative damage in Caenorhabditis elegans

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Maintenance on L-deprenyl prolongs life in aged male rats

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Physical-chemical and biochemical differences in liver plasma membranes in aging F-344 rats

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Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

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Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats

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Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice

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Sex-dependent differences in the effects of aging on antioxidant defense mechanisms of rat liver

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Treatment with L-deprenyl prolongs life in elderly dogs

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Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction

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Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males.

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Age-dependence of the lateral mobility of lipids in hepatocyte plasma membrane of male rats and the effect of life-long dietary restriction

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10.1016/S0047-6374(99)00065-2

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24 November 2022

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