(Q28370855)

English

A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme

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A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme (English)

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author name string

B T Akingbemi

1

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R S Ge

2

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G R Klinefelter

3

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G L Gunsalus

4

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M P Hardy

5

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language of work or name

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publication date

March 2000

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Biology of Reproduction

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62

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3

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571-8

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Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract

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Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem

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Carcinogenicity and toxicity of methoxychlor

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A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat.

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Pesticides: multiple mechanisms of demasculinization

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Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation

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Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays

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Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA.

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The primary structure of rat ribosomal protein S16.

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Substrate-binding region of cytochrome P-450SCC (P-450 XIA1). Identification and primary structure of the cholesterol binding region in cytochrome P-450SCC.

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Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes.

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The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function

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Estrogen receptor messenger ribonucleic acid changes during Leydig cell development

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Developmental effects of endocrine-disrupting chemicals in wildlife and humans

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Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications

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Effects of Estrogens on Testicular Testosterone Production in vitro

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Tetrahydroisoquinoline alkaloids mimic direct but not receptor-mediated inhibitory effects of estrogens and phytoestrogens on testicular endocrine function. Possible significance for Leydig cell insufficiency in alcohol addiction.

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Direct Inhibition of Leydig Cell Function by Estradiol*

1 reference

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Inhibitory effects of technical grade methoxychlor on development of neonatal male mouse reproductive organs

1 reference

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Multistep regulation of Leydig cell function

1 reference

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Molecular basis of agonism and antagonism in the oestrogen receptor

1 reference

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10.1095/BIOLREPROD62.3.571

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