(Q28373096)

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WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity

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WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity (English)

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author name string

O J D'Cruz

1

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Z Zhu

2

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S H Yiv

3

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C L Chen

4

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B Waurzyniak

5

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F M Uckun

6

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language of work or name

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publication date

May 1999

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59

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5

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319-31

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Global burden of the HIV pandemic

1 reference

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Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?

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T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen

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The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa.

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A dosing study of nonoxynol-9 and genital irritation

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Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes

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Condom and nonoxynol-9 use and the incidence of HIV infection in serodiscordant couples in Zambia

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The urgent need for a vaginal microbicide in the prevention of HIV transmission

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Safety Study of Nonoxynol-9 as a Vaginal Microbicide: Evidence of Adverse Effects

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Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1.

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Nonoxynol-9 fails to protect against HIV-1.

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A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases

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Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus

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Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).

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Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

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Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies

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Recombinant soluble human complement receptor type 1 inhibits antisperm antibody- and neutrophil-mediated injury to human sperm

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Spermicidal activity of metallocene complexes containing vanadium(IV) in humans

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Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity

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Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys

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Ultrastructure of Human Spermatozoa in the Presence of the Spermicide Nonoxinol-9 and a Vaginal Contraceptive Containing Nonoxinol-9

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Scanning electron microscopy of human spermatozoa after incubation with the spermicide nonoxynol-9

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Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities

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10.1016/S0010-7824(99)00041-4

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