(Q28373841)

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Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons

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Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons (English)

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polycyclic aromatic hydrocarbons

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author name string

W A Kappers

1

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F M van Och

2

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E M de Groene

3

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G J Horbach

4

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language of work or name

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publication date

23 March 2000

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Mutation Research

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466

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2

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143-59

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Cytogenetic effects of promutagens in genetically engineered V79 Chinese hamster cells expressing cytochromes P450.

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Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays

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A NIH/3T3 cell line stably expressing human cytochrome P450-3A4 used in combination with a lacZ' shuttle vector to study mutagenicity

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Detection of 1-nitropyrene in yakitori (grilled chicken).

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Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal

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Mutagenicity of mono- and dinitropyrenes in the Salmonella typhimurium TM677 forward mutation assay

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Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons

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Early formation of DNA adducts compared with tumor formation in a long-term tumor study in rats after administration of 2-nitrofluorene

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The metabolism of 1-nitropyrene by human cytochromes P450.

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In vivo and in vitro formation of glutathione conjugates from the K-region epoxides of 1-nitropyrene

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Formation of mutagenic urinary metabolites from 1-nitropyrene in germ-free and conventional rats: role of the gut flora

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Xanthine oxidase catalyzed binding of 1-nitropyrene to DNA

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Aerobic and anaerobic reduction of nitrated pyrenes in vitro

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β-estradiol and 2-aminofluorene in V79 Chinese hamster cells

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Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

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Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.

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Mechanisms of frameshift mutations: insight from aromatic amines

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Human P3(450): cDNA and complete amino acid sequence

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35 N-acetyltransferase and arylhydroxamic acid acyltransferase

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Toxicity determined in vitro by morphological alterations and neutral red absorption

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10.1016/S1383-5718(00)00015-2

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