(Q28386926)

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Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis

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Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosis (English)

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author name string

Yong-Hun Lee

1

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William P Schiemann

2

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language of work or name

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publication date

25 February 2011

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Journal of Biological Chemistry

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286

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8

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6414-22

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21156791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21156791

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based on heuristic

inferred from PubMed ID database lookup

Matrix Metalloproteinases-2 and -9 are Secreted from Human Fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21156791

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based on heuristic

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Identifiers

10.1074/JBC.M110.168682

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