(Q28391230)

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Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells

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Europe PubMed Central

Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells (English)

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hepatocellular carcinoma

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author name string

Yan-Nian Chen

1

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Chi-Chih Cheng

2

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Jung-Chou Chen

3

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Wei Tsauer

4

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Shih-Lan Hsu

5

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language of work or name

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publication date

October 2003

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British Journal of Pharmacology

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140

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3

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461-70

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1 reference

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From receptors to stress-activated MAP kinases

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20 March 2017

Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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20 March 2017

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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AP-1 as a regulator of cell life and death

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AP-1 in cell proliferation and survival

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C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP.

1 reference

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The JNK signal transduction pathway

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1 reference

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1 reference

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29 September 2017

Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells.

1 reference

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Effect of norcantharidin on N-acetyltransferase activity in HepG2 cells

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29 September 2017

Norcantharidin-induced post-G(2)/M apoptosis is dependent on wild-type p53 gene

1 reference

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29 September 2017

Requirement for ERK activation in cisplatin-induced apoptosis

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Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

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29 September 2017

New insights into the control of MAP kinase pathways

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Generation of reactive oxygen intermediates, activation of NF-kappaB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?

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Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.

1 reference

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NF-kappaB to the rescue: RELs, apoptosis and cellular transformation

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Multiple signals converging on NF-kappaB.

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Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

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Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

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The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

1 reference

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29 September 2017

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

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Role of MAP kinase in neurons

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Nonradioactive gel mobility shift assay using chemiluminescent detection

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https://pubmed.ncbi.nlm.nih.gov/12970086

12 December 2020

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[Studies on antitumor agents II: synthesis and anticancer activity of dehydrogenated carboncyclic analogs of norcantharidin]

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Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival

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https://pubmed.ncbi.nlm.nih.gov/12970086

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https://pubmed.ncbi.nlm.nih.gov/12970086

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Identifiers

10.1038/SJ.BJP.0705461

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