(Q28508200)

English

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition

scientific journal article

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scholarly article

1 reference

24 January 2017

Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition (English)

1 reference

24 January 2017

Glutamate receptor, ionotropic, NMDA2A (epsilon 1)

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Will Spooren

1

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24 January 2017

Cedric Mombereau

2

1 reference

24 January 2017

Martine Maco

3

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24 January 2017

Rammy Gill

4

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24 January 2017

John A. Kemp

5

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24 January 2017

Laurence Ozmen

6

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24 January 2017

Shigetada Nakanishi

7

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24 January 2017

Guy A. Higgins

8

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24 January 2017

language of work or name

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inferred from title

publication date

1 August 2004

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24 January 2017

Psychopharmacology

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24 January 2017

175

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24 January 2017

99–105

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24 January 2017

1

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24 January 2017

https://scigraph.springernature.com/pub.10.1007/s00213-004-1785-y

0 references

N-methyl-D-aspartic acid receptor structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-ischaemic drug, eliprodil, blocks hyperactivity induced by intra-accumbens injection of spermine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical experience with excitatory amino acid antagonist drugs

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https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of dopaminergic mechanisms in the stimulatory effects of MK-801 injected into the ventral tegmental area and the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inbred strain differences in prepulse inhibition of the mouse startle response

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor pathways as drug targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gating and habituation of the startle reflex in schizophrenic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of N-methyl- d-aspartate glutamate receptor subunits in the prefrontal cortex of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of locomotor activity, acoustic and tactile startle, and prepulse inhibition of startle in inbred mouse strains and F1 hybrids: implications of genetic background for single gene and quantitative trait loci analyses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonists selective for NMDA receptors containing the NR2B subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prepulse inhibition of the startle reflex in rats: effects of compounds acting at various sites on the NMDA receptor complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the phencyclidine model of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic and knock-out mouse pups: the growing need for behavioral analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The behavioral pharmacology of NMDA receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive NMDA receptor antagonists do not produce locomotor hyperactivity by a dopamine-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14985927

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-004-1785-Y

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1 reference

24 January 2017

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