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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
title
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
(English)
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
main subject
stem cell self-renewal
1 reference
based on heuristic
inferred from title
stem-cell quiescence
1 reference
based on heuristic
inferred from title
author name string
Alexey Bersenev
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
Chao Wu
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
Joanna Balcerek
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
Wei Tong
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
language of work or name
English
0 references
publication date
1 August 2008
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
published in
Journal of Clinical Investigation
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
volume
118
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
issue
8
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
page(s)
2832–2844
1 reference
stated in
PubMed
PubMed ID
18618018
retrieved
24 January 2017
cites work
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
1 reference
stated in
PubMed Central
reference URL
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19 March 2017
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
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PubMed Central
reference URL
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retrieved
19 March 2017
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
19 March 2017
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
19 March 2017
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta
1 reference
stated in
PubMed Central
reference URL
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19 March 2017
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
1 reference
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PubMed Central
reference URL
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retrieved
19 March 2017
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
19 March 2017
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
Jak2 is essential for signaling through a variety of cytokine receptors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
19 March 2017
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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19 March 2017
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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7 April 2017
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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7 April 2017
A gain-of-function mutation of JAK2 in myeloproliferative disorders
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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7 April 2017
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
29 September 2017
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Thrombopoietin: a tool for understanding thrombopoiesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Thrombopoietin expands hematopoietic stem cells after transplantation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Lnk adaptor: novel negative regulator of B cell lymphopoiesis
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
1 reference
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PubMed Central
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29 September 2017
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Thrombocytopenia in c-mpl-deficient mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Flow cytometric estimation of DNA and RNA content in intact cells stained with hoechst 33342 and pyronin Y
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
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29 September 2017
Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure
1 reference
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PubMed Central
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29 September 2017
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy
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PubMed Central
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29 September 2017
Effects of transplantation on the primitive immunohematopoietic stem cell
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PubMed Central
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29 September 2017
Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging
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29 September 2017
Role of c-mpl in early hematopoiesis.
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2 June 2018
Structure and function of the cytokine receptor superfamily.
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2 June 2018
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
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27 November 2018
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
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27 November 2018
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
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PubMed Central
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27 November 2018
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.
1 reference
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27 November 2018
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events
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27 November 2018
Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice
1 reference
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27 November 2018
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
1 reference
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PubMed Central
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27 November 2018
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929
retrieved
27 November 2018
Permanent loss in stem cell self renewal capacity following stress to the marrow
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18618018
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18618018
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18618018
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI35808
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2114753
OpenCitations bibliographic resource ID
2114753
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2114753
PMCID
2447929
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2114753
PubMed ID
18618018
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2114753
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