(Q28509472)

24 January 2017

title

VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis (English)

1 reference

FMS-like tyrosine kinase 4

24 January 2017

main subject

1 reference

GOA release 2020-03-11

1 reference

1 reference

1 reference

Luqing Zhang

1

1 reference

24 January 2017

Fei Zhou

2

1 reference

24 January 2017

Wencan Han

3

1 reference

24 January 2017

Bin Shen

4

1 reference

24 January 2017

Jincai Luo

5

1 reference

24 January 2017

Masabumi Shibuya

6

1 reference

24 January 2017

Yulong He

7

1 reference

24 January 2017

language of work or name

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1 December 2010

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24 January 2017

1 reference

24 January 2017

volume

20

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24 January 2017

issue

12

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24 January 2017

page(s)

1319–1331

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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.

24 January 2017

cites work

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VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer

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Molecular regulation of angiogenesis and lymphangiogenesis

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Transcriptional control of endothelial cell development.

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Prox1 function is required for the development of the murine lymphatic system

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Sox18 induces development of the lymphatic vasculature in mice

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VEGF receptor signal transduction

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The biology of VEGF and its receptors

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Proteolytic processing regulates receptor specificity and activity of VEGF-C.

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7 January 2021

Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers

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MAPping out arteries and veins.

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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

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7 January 2021

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

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7 January 2021

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

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7 January 2021

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

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7 January 2021

Cardiovascular failure in mouse embryos deficient in VEGF receptor-3

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7 January 2021

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos

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7 January 2021

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

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7 January 2021

LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan

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7 January 2021

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels

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7 January 2021

A model for gene therapy of human hereditary lymphedema

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7 January 2021

Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1.

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Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

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7 January 2021

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

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7 January 2021

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

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7 January 2021

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels

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7 January 2021

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

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7 January 2021

Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

1 reference

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7 January 2021

Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration

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7 January 2021

Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity

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7 January 2021

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.

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7 January 2021

A highly efficient recombineering-based method for generating conditional knockout mutations

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7 January 2021

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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7 January 2021

Widespread recombinase expression using FLPeR (flipper) mice

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7 January 2021

A protocol for isolation and culture of human umbilical vein endothelial cells.

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7 January 2021

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

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7 January 2021

Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.

1 reference

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7 January 2021