(Q28543670)

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Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects

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scholarly article

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Morphine and clonidine combination therapy improves therapeutic window in mice: synergy in antinociceptive but not in sedative or cardiovascular effects (English)

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circulatory system

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based on heuristic

inferred from title

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Laura S Stone

1

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Jonathan P German

2

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Kelly F Kitto

3

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Carolyn A Fairbanks

4

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George L Wilcox

5

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language of work or name

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publication date

2014

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9

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10

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e109903

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copyright license

Creative Commons Attribution 4.0 International

9 October 2014

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April 2022 Public Data File from Crossref

copyright status

0 references

Combination pharmacotherapy for the treatment of neuropathic pain in adults

1 reference

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19 March 2017

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats

1 reference

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19 March 2017

Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

1 reference

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7 April 2017

Ethical guidelines for investigations of experimental pain in conscious animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

7 April 2017

Combination pharmacotherapy for management of chronic pain: from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Alpha2-agonists as analgesic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

RETRACTED: The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Postcesarean analgesia with spinal morphine, clonidine, or their combination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Intrathecal clonidine in the treatment of intractable pain: a phase I/II study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Epidural and intrathecal analgesia for cancer pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Combination spinal analgesic chemotherapy: a systematic review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Epidural clonidine treatment for refractory reflex sympathetic dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Synergistic antinociceptive interactions among drugs administered to the spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

An Isobolographic Study of Epidural Clonidine and Fentanyl After Cesarean Section

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Intrathecal and epidural administration of opioids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Epidural clonidine analgesia following surgery: phase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Statistical analysis of drug combinations for synergism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

29 September 2017

Morphine and clonidine synergize to ameliorate low back pain in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Intrathecal morphine and clonidine in the management of spinal cord injury pain: a case report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Studies in the Primate on the Analgetic Effects Associated with Intrathecal Actions of Opiates,α-Adrenergic Agonists and Baclofen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Analgesia produced by clonidine in mice and rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Analgesia and autonomic function following intrathecal administration of morphine and norepinephrine to the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

A study of the interaction between clonidine and morphine on analgesia and blood pressure during continuous intrathecal infusion in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Epidural clonidine analgesia for intractable cancer pain: phase I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

An isobolographic analysis of the antinociceptive effect of systemically and intrathecally administered combinations of clonidine and opiates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Antinociceptive interaction between opioids and medetomidine: systemic additivity and spinal synergy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Antinociceptive and motor effects of intrathecal morphine combined with intrathecal clonidine, noradrenaline, carbachol or midazolam in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

Intravenous morphine-induced activation of vagal afferents: peripheral, spinal, and CNS substrates mediating inhibition of spinal nociception and cardiovascular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

3 June 2018

The delta-opioid receptor is sufficient, but not necessary, for spinal opioid-adrenergic analgesic synergy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109903

21 January 2018

The interaction index: a measure of drug synergism

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109903

21 January 2018

The effect of clonidine on intra-operative requirements of fentanyl during combined epidural/general anaesthesia.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0109903

21 January 2018

A randomized, double-blinded trial of subarachnoid bupivacaine and fentanyl, with or without clonidine, for combined spinal/epidural analgesia during labor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

27 November 2018

Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

27 November 2018

Decreased spinal morphine/clonidine antinociceptive synergism in morphine-tolerant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

27 November 2018

Subarachnoid neostigmine potentiation of alpha 2-adrenergic agonist analgesia. Dexmedetomidine versus Clonidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

27 November 2018

Epidural clonidine analgesia after cesarean section.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192360

27 November 2018

Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of morphine and clonidine on gastrointestinal transit in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal noradrenergic terminal system mediates antinociception

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moxonidine, a selective imidazoline-alpha2 -adrenergic receptor agonist, produces spinal synergistic antihyperalgesia with morphine in nerve-injured mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal cord pharmacology of adrenergic agonist-mediated antinociception

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of alpha adrenoceptors involved in the antinociceptive and cardiovascular effects of intrathecally administered clonidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal morphine in mice: a new technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on blood pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous intrathecal clonidine administration for the treatment of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous intrathecal hydromorphone and clonidine for intractable cancer pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25299457

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0109903

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...9j9903S

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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