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Thrombopoietin
mammalian protein found in Rattus norvegicus
Thpo
thrombopoietin
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
17 June 2020
UniProt protein ID
P49745
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
P49745
part of
four-helical cytokine-like, core
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P49745
Thrombopoeitin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P49745
Erythropoietin/thrombopoeitin, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
brown rat
1 reference
stated in
UniProt
retrieved
17 June 2020
UniProt protein ID
P49745
encoded by
Thpo
1 reference
stated in
UniProt
retrieved
8 June 2017
UniProt protein ID
P49745
Thpo
1 reference
stated in
UniProt
retrieved
17 June 2020
UniProt protein ID
P49745
molecular function
signaling receptor binding
determination method
IBA
IDA
2 references
retrieved
14 February 2019
stated in
The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
cytokine activity
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
hormone activity
determination method
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
cell component
extracellular region
determination method
IBA
IDA
IEA
4 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
retrieved
14 February 2019
stated in
Hepatic thrombopoietin mRNA is increased in acute inflammation
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
extracellular space
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
biological process
positive regulation of protein phosphorylation
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
ISS
cell population proliferation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
positive regulation of cell population proliferation
determination method
IBA
IDA
2 references
retrieved
14 February 2019
stated in
Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
regulation of signaling receptor activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEA
response to lipopolysaccharide
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Hepatic thrombopoietin mRNA is increased in acute inflammation
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEP
thrombopoietin-mediated signaling pathway
determination method
IBA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
ISS
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
positive regulation of megakaryocyte differentiation
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
ISS
positive regulation of protein kinase B signaling
determination method
ISS
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
ISS
positive regulation of ERK1 and ERK2 cascade
determination method
IBA
ISS
2 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49745
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
ISS
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
cellular response to lipopolysaccharide
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Inflammation stimulates thrombopoietin (Tpo) expression in rat brain-derived microvascular endothelial cells, but suppresses Tpo in astrocytes and microglia
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IEP
positive regulation of hematopoietic stem cell proliferation
determination method
IBA
1 reference
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49745
determination method
IBA
has part(s)
Erythropoietin/thrombopoeitin, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P49745
Identifiers
RefSeq protein ID
XP_008767049
1 reference
stated in
NCBI Gene
retrieved
15 February 2020
Entrez Gene ID
108348162
XP_008767050
1 reference
stated in
NCBI Gene
retrieved
15 February 2020
Entrez Gene ID
108348162
XP_008767051
1 reference
stated in
NCBI Gene
retrieved
15 February 2020
Entrez Gene ID
108348162
XP_017453669
1 reference
stated in
NCBI Gene
retrieved
15 February 2020
Entrez Gene ID
108348162
XP_017453670
1 reference
stated in
NCBI Gene
retrieved
15 February 2020
Entrez Gene ID
108348162
UniProt protein ID
P49745
1 reference
stated in
UniProt
retrieved
17 June 2020
UniProt protein ID
P49745
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