(Q28558654)

Transcription factor, Skn-1-like, DNA-binding domain superfamily

1 reference

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Basic leucine zipper domain, Maf-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

transcription coregulator binding

1 reference

14 February 2019

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

DNA-binding transcription activator activity, RNA polymerase II-specific

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

3 references

DNA-binding transcription factor activity

IBA

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

protein domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

sequence-specific DNA binding

1 reference

14 February 2019

Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

biological process

inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

1 reference

14 February 2019

Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of gene expression

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of cardiac muscle cell apoptotic process

1 reference

14 February 2019

Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of neuron projection development

1 reference

14 February 2019

Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

protein ubiquitination

positive regulation of blood coagulation

ISS

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

endoplasmic reticulum unfolded protein response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to oxidative stress

IBA

response to endoplasmic reticulum stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of transcription from RNA polymerase II promoter in response to stress

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

1 reference

14 February 2019

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

PERK-mediated unfolded protein response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to glucose starvation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of blood vessel endothelial cell migration

1 reference

14 February 2019

Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cell redox homeostasis

positive regulation of angiogenesis

ISS

2 references

1 reference

14 February 2019

Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

regulation of embryonic development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

aflatoxin catabolic process

1 reference

14 February 2019

Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of glucose import

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to tumor necrosis factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to hypoxia

1 reference

14 February 2019

Knockdown of Nrf2 inhibits the angiogenesis of rat cardiac micro-vascular endothelial cells under hypoxic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to laminar fluid shear stress

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of hematopoietic stem cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of hydrogen peroxide-induced cell death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of glutathione biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

cellular response to angiotensin

1 reference

14 February 2019

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of vascular associated smooth muscle cell migration

IEP

1 reference

14 February 2019

Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

regulation of removal of superoxide radicals

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

negative regulation of endothelial cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

positive regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54968

Basic leucine zipper domain, Maf-type

has part(s)

1 reference

Basic-leucine zipper domain

1 reference