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Menin 1
mammalian protein found in Rattus norvegicus
Men1
multiple endocrine neoplasia type I
multiple endocrine neoplasia I
menin
multiple endocrine neoplasia 1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9WVR8
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
Q9WVR8
part of
Menin
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9WVR8
found in taxon
brown rat
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9WVR8
encoded by
Men1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9WVR8
molecular function
four-way junction DNA binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
Y-form DNA binding
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
molecular function
determination method
ND
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WVR8&geneProductId=UniProtKB:Q9WVR8
determination method
ND
DNA binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WVR8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
chromatin binding
determination method
IBA
IDA
2 references
retrieved
14 February 2019
stated in
Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
double-stranded DNA binding
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
histone-lysine N-methyltransferase activity
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
protein-macromolecule adaptor activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
protein N-terminus binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
R-SMAD binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
cell component
chromatin
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
nucleus
determination method
IDA
IEA
5 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WVR8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Structure and distribution of rat menin mRNA
GOA
curator
UniProt
UniProt protein ID
Q9WVR8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IDA
retrieved
14 February 2019
stated in
Structure and distribution of rat menin mRNA
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IDA
nucleoplasm
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
cytoplasm
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
cytosol
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
nuclear matrix
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
cleavage furrow
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
protein-containing complex
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
histone methyltransferase complex
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
biological process
negative regulation of transcription by RNA polymerase II
determination method
IEA
IMP
2 references
retrieved
14 February 2019
stated in
Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
MAPK cascade
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
mitotic cell cycle
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Cell cycle regulation of menin expression
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEP
negative regulation of protein phosphorylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
osteoblast development
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
type B pancreatic cell differentiation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
chromatin organization
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WVR8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
cellular response to DNA damage stimulus
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
brain development
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Structure and distribution of rat menin mRNA
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEP
negative regulation of cell population proliferation
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
response to UV
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
response to gamma radiation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
negative regulation of cell-substrate adhesion
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
positive regulation of transforming growth factor beta receptor signaling pathway
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
positive regulation of protein binding
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
regulation of activin receptor signaling pathway
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and menin
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
histone lysine methylation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
negative regulation of DNA-binding transcription factor activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
negative regulation of osteoblast differentiation
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
negative regulation of cyclin-dependent protein serine/threonine kinase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
negative regulation of cell cycle
determination method
IBA
IEA
2 references
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IBA
negative regulation of transcription, DNA-templated
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
positive regulation of transcription by RNA polymerase II
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
negative regulation of JNK cascade
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
decidualization
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEP
negative regulation of epithelial cell proliferation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
negative regulation of telomerase activity
determination method
IEA
1 reference
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEA
regulation of type B pancreatic cell proliferation
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
cellular response to glucose stimulus
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Glucose-mediated repression of menin promotes pancreatic β-cell proliferation
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEP
cellular response to peptide hormone stimulus
determination method
IEP
1 reference
retrieved
14 February 2019
stated in
Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IEP
response to transforming growth factor beta
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
negative regulation of cell cycle G1/S phase transition
determination method
IMP
1 reference
retrieved
14 February 2019
stated in
Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVR8
determination method
IMP
Identifiers
RefSeq protein ID
NP_062081
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_006230831
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_006230832
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_006230833
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_006230834
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_038965304
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
XP_038965306
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
29417
UniProt protein ID
Q9WVR8
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9WVR8
Ensembl protein ID
ENSRNOP00000028592
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000028592
ENSRNOP00000076697
1 reference
stated in
ensembl Release 106
Ensembl protein ID
ENSRNOP00000076697
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