(Q28559472)

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine/threonine-protein kinase OSR1/WNK, CCT domain, protein family

1 reference

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

magnesium ion binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

IMP

protein kinase activity

2 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

protein serine/threonine kinase activity

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Comparison of WNK4 and WNK1 kinase and inhibiting activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

protein kinase inhibitor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

3 references

14 February 2019

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Comparison of WNK4 and WNK1 kinase and inhibiting activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

2 references

protein serine/threonine kinase inhibitor activity

1 reference

14 February 2019

Comparison of WNK4 and WNK1 kinase and inhibiting activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

protein kinase activator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

1 reference

14 February 2019

Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

regulation of sodium ion transport

biological process

1 reference

14 February 2019

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of systemic arterial blood pressure

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

protein phosphorylation

7 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Comparison of WNK4 and WNK1 kinase and inhibiting activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of protein kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

2 references

negative regulation of sodium ion transport

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of T cell chemotaxis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

peptidyl-serine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

activation of protein kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of ion transmembrane transporter activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of cell-cell adhesion mediated by integrin

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of kinase activity

1 reference

14 February 2019

Comparison of WNK4 and WNK1 kinase and inhibiting activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of heterotypic cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of GTPase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

intracellular signal transduction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

chemokine (C-C motif) ligand 21 signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

T cell receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

cellular response to calcium ion

1 reference

14 February 2019

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of protein serine/threonine kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of pancreatic juice secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

lymphocyte migration into lymph node

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

negative regulation of leukocyte cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of potassium ion import across plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

cellular response to chemokine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

positive regulation of sodium ion transmembrane transporter activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JIH7

has part(s)

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference

Serine/threonine-protein kinase OSR1/WNK, CCT domain

1 reference