(Q28560846)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, LIM-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

transcription coactivator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

Functional analysis of the nuclear LIM domain interactor NLI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

estrogen receptor binding

IPI

1 reference

14 February 2019

The LIM/homeodomain protein islet-1 modulates estrogen receptor functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

bHLH transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

Expression, purification and characterization of the homeodomain of rat ISL-1 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

1 January 2018

The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of transcription by RNA polymerase II

IBA

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

neural crest cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

secondary heart field specification

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

outflow tract septum morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

outflow tract morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

endocardial cushion morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

cardiac right ventricle morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

regulation of secondary heart field cardioblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

2 references

positive regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of vascular endothelial growth factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

spinal cord motor neuron cell fate specification

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

spinal cord motor neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

visceral motor neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

trigeminal nerve development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

pituitary gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

Regulation of the LIM-type homeobox gene islet-1 during neuronal regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

retinal ganglion cell axon guidance

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of insulin secretion

1 reference

14 February 2019

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of granulocyte macrophage colony-stimulating factor production

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of interferon-gamma production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of interleukin-1 alpha production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of interleukin-1 beta production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of interleukin-12 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of interleukin-6 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of tumor necrosis factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of intracellular estrogen receptor signaling pathway

1 reference

14 February 2019

The LIM/homeodomain protein islet-1 modulates estrogen receptor functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of histone acetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of neuron apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of transcription by RNA polymerase II

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

1 January 2018

The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

1 January 2018

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

neuron fate commitment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

neuron fate specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61374&geneProductId=UniProtKB:P61374

mesenchymal cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

sensory system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

peripheral nervous system neuron development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

peripheral nervous system neuron axonogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of epithelial cell proliferation

1 reference

14 February 2019

Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of inflammatory response

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

ventricular cardiac muscle tissue morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

pharyngeal system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

cardiac muscle cell myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

atrial septum morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

cardiac cell fate determination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

cellular response to glucocorticoid stimulus

1 reference

14 February 2019

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of granulocyte colony-stimulating factor production

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of protein homodimerization activity

1 reference

14 February 2019

The LIM/homeodomain protein islet-1 modulates estrogen receptor functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

negative regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of macrophage colony-stimulating factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

positive regulation of transcription by RNA polymerase II

IBA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61374

1 reference

Homeobox, conserved site

1 reference

stated in

Zinc finger, LIM-type

1 reference

stated in