(Q28561858)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00959

ionotropic glutamate receptor, metazoa

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q00959

Transporter Classification Database ID

1.A.10.1.6

retrieved

2 October 2019

hierarchical database ID heuristic

Receptor, ligand binding region, protein family

1 reference

Ionotropic glutamate receptor domain, protein family

1 reference

Glutamate [NMDA] receptor, epsilon subunit, C-terminal domain, protein family

1 reference

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain, protein family

1 reference

ionotropic glutamate receptor activity

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 May 2019

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

NMDA glutamate receptor activity

7 references

9 May 2019

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

signaling receptor binding

IBA

1 reference

9 May 2019

Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

extracellularly glutamate-gated ion channel activity

1 reference

9 May 2019

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor

cation channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 references

9 May 2019

Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion

protein kinase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

voltage-gated cation channel activity

1 reference

9 May 2019

Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

glutamate-gated calcium ion channel activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

glutamate receptor binding

ISS

1 reference

9 May 2019

NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

signaling receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Prenatal development of NMDA receptor composition and function in trigeminal neurons

neurotransmitter binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

protein-containing complex binding

2 references

9 May 2019

Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

protein heterodimerization activity

1 reference

9 May 2019

Amino terminal domains of the NMDA receptor are organized as local heterodimers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

protein dimerization activity

1 reference

9 May 2019

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cell adhesion molecule binding

1 reference

9 May 2019

A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors

scaffold protein binding

1 reference

9 May 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

integral component of plasma membrane

integral component of membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

NMDA selective glutamate receptor complex

6 references

9 May 2019

Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

postsynaptic membrane

1 reference

14 February 2019

parallel fiber to Purkinje cell synapse

1 reference

9 May 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

postsynaptic density membrane

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

IBA

glutamatergic synapse

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Subunit-specific NMDA receptor trafficking to synapses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Subunit-specific NMDA receptor trafficking to synapses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

integral component of presynaptic membrane

EXP

1 reference

9 May 2019

Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

9 May 2019

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

chemical synaptic transmission

biological process

1 reference

9 May 2019

Reaction mechanism determines NMDA receptor response to repetitive stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

response to light stimulus

1 reference

9 May 2019

Experience-dependent regulation of NMDA receptor subunit composition and phosphorylation in the retina and visual cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats

response to carbohydrate

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

response to manganese ion

1 reference

9 May 2019

Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

positive regulation of cell death

1 reference

9 May 2019

Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

response to organic cyclic compound

1 reference

9 May 2019

Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

calcium-mediated signaling

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat

spinal cord development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition

hippocampus development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cerebral cortex development

1 reference

9 May 2019

Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

ionotropic glutamate receptor signaling pathway

1 reference

9 May 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

1 reference

9 May 2019

Prenatal development of NMDA receptor composition and function in trigeminal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors

protein tetramerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices

response to calcium ion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

response to methylmercury

1 reference

9 May 2019

Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

response to other organism

1 reference

9 May 2019

Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

long-term potentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Effects of ammonia and allopurinol on rat hippocampal NMDA receptors

IBA

response to ammonium ion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate

response to fungicide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to amino acid stimulus

1 reference

9 May 2019

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to magnesium ion

1 reference

9 May 2019

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to manganese ion

1 reference

9 May 2019

Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to zinc ion

1 reference

9 May 2019

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to dsRNA

1 reference

9 May 2019

Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to growth factor stimulus

1 reference

9 May 2019

Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

cellular response to lipid

1 reference

9 May 2019

The effect of ganglioside GQ1b on the NMDA receptor signaling pathway in H19-7 cells and rat hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

calcium ion transmembrane import into cytosol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

regulation of presynaptic membrane potential

ISS

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

positive regulation of excitatory postsynaptic potential

1 reference

9 May 2019

Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

dendritic spine organization

1 reference

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

regulation of NMDA receptor activity

1 reference

9 May 2019

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00959

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1.A.10.1.6

2 references

Transporter Classification database

retrieved

13 March 2020