(Q28771352)

English

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors

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PubMed publication ID

14 February 2017

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors (English)

1 reference

PubMed publication ID

14 February 2017

author name string

Hongjie Yuan

1

1 reference

PubMed publication ID

14 February 2017

Katie M. Vance

2

1 reference

PubMed publication ID

14 February 2017

Candice E. Junge

3

1 reference

PubMed publication ID

14 February 2017

Matthew T. Geballe

4

1 reference

PubMed publication ID

14 February 2017

James P. Snyder

5

1 reference

PubMed publication ID

14 February 2017

John R. Hepler

6

1 reference

PubMed publication ID

14 February 2017

Manuel Yepes

7

1 reference

PubMed publication ID

14 February 2017

Chian-Ming Low

8

1 reference

PubMed publication ID

14 February 2017

Stephen F. Traynelis

9

1 reference

PubMed publication ID

14 February 2017

language of work or name

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publication date

8 May 2009

1 reference

PubMed publication ID

14 February 2017

Journal of Biological Chemistry

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PubMed publication ID

14 February 2017

284

1 reference

PubMed publication ID

14 February 2017

19

1 reference

PubMed publication ID

14 February 2017

12862–12873

1 reference

PubMed publication ID

14 February 2017

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

16 March 2017

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

16 March 2017

The glutamate receptor ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

16 March 2017

The biochemical basis of zinc physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

7 April 2017

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

White matter NMDA receptors: an unexpected new therapeutic target?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Protease-activated receptor signaling: new roles and regulatory mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Astrocytic control of synaptic NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

NMDA receptor subunits: function and pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The neurobiology of zinc in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Glutamate receptor gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Proteases involved in long-term potentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

NMDA receptor pathways as drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Protease-activated receptors: how proteases signal to cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Specific proteolysis of the NR2 subunit at multiple sites by calpain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Serine proteases and brain damage - is there a link?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The actions of synaptically released zinc at hippocampal mossy fiber synapses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Zinc and brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Zinc metabolism in the brain: relevance to human neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

High-affinity zinc inhibition of NMDA NR1-NR2A receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Plasmin-mediated proteolysis of osteocalcin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Molecular genetics of the fibrinolytic and coagulation systems in haemostasis, thrombogenesis, restenosis and atherosclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Clinical implications of the involvement of tPA in neuronal cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Possible involvement of plasmin in long-term potentiation of rat hippocampal slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Separating dual effects of zinc at recombinant N-methyl-D-aspartate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Neuroprotective actions of excitatory amino acid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Characterization of peptides cleaved by plasmin from the C-terminal polymerization domain of human fibrinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Amino acid sequence studies on the α chain of human fibrinogen. Location of four plasmin attack points and a covalent cross-linking site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

3 June 2018

Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Modulation of triheteromeric NMDA receptors by N-terminal domain ligands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Activation of pro-BDNF by the pericellular serine protease plasmin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Calpain-mediated regulation of NMDA receptor structure and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Acute tissue damage after injections of thrombin and plasmin into rat striatum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Multiple panel of biomarkers for TIA/stroke evaluation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805123200

21 January 2018

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676017

26 November 2018

Plasmin converts factor X from coagulation zymogen to fibrinolysis cofactor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of NMDA receptor function by the serine protease thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Neuronal Apoptosis by Thiol Oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gas-liquid solid phase peptide and protein sequenator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasmin cleavage of vitronectin Identification of the site and consequent attenuation in binding plasminogen activator inhibitor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator for acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/19240037

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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