(Q28563254)

GroEL-like apical domain superfamily

1 reference

GroEL-like equatorial domain superfamily

1 reference

TCP-1-like chaperonin intermediate domain superfamily

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Chaperonin Cpn60, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

lipopolysaccharide binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

4 references

8 April 2019

Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Cytosolic heat shock protein 60, apoptosis, and myocardial injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

protein-containing complex binding

IPI

1 reference

8 April 2019

Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

protein heterodimerization activity

IPI

1 reference

8 April 2019

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IPI

unfolded protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

modification-dependent protein binding

IBA

1 reference

8 April 2019

Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

mitochondrial inner membrane

IBA

1 reference

8 April 2019

Presence of Chromatium vinosum chaperonins 10 and 60 in mitochondria and peroxisomes of rat hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Presence of Chromatium vinosum chaperonins 10 and 60 in mitochondria and peroxisomes of rat hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

rough endoplasmic reticulum

3 references

8 April 2019

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Cytosolic heat shock protein 60, apoptosis, and myocardial injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Expression of mitochondrial heat shock protein 60 in distinct cell types and defined stages of rat seminiferous epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Possible association of chaperonin 60 with secretory proteins in pancreatic acinar cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Subcellular stress response after traumatic brain injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

mitochondrion organization

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

response to organic substance

ISS

1 reference

8 April 2019

Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

response to organic cyclic compound

1 reference

8 April 2019

Differential protein expression in pancreatic islets after treatment with an imidazoline compound

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Exercise training and experimental diabetes modulate heat shock protein response in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

response to lipopolysaccharide

1 reference

8 April 2019

Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

positive regulation of interferon-alpha production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

positive regulation of interferon-gamma production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

cellular response to heat

1 reference

8 April 2019

Temporal variations of Hsp60 and HSF-1 in primary rat myocardial cells in vitro under heat stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

response to hydrogen peroxide

1 reference

8 April 2019

Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

negative regulation of apoptotic process

1 reference

8 April 2019

Cytosolic heat shock protein 60, apoptosis, and myocardial injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

negative regulation of neuron apoptotic process

IMP

1 reference

8 April 2019

Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

1 reference

8 April 2019

Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

protein import into mitochondrial intermembrane space

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

positive regulation of inflammatory response

IBA

1 reference

8 April 2019

Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

positive regulation of T cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

response to glucocorticoid

1 reference

8 April 2019

Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

negative regulation of apoptotic process in bone marrow cell

1 reference

8 April 2019

Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

cellular response to interleukin-7

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

negative regulation of reactive oxygen species biosynthetic process

1 reference

8 April 2019

HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63039

Chaperonin Cpn60, conserved site

IMP

has part(s)

1 reference