(Q28579256)

21 June 2017

title

A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel (English)

1 reference

21 June 2017

Touran Zarrabi

1

1 reference

21 June 2017

Rene Cervenka

2

1 reference

21 June 2017

Walter Sandtner

3

1 reference

21 June 2017

Peter Lukacs

4

1 reference

21 June 2017

Xaver Koenig

5

1 reference

21 June 2017

Karlheinz Hilber

6

1 reference

21 June 2017

Markus Mille

7

1 reference

21 June 2017

Hannes Todt

10

1 reference

21 June 2017

Gregory M Lipkind

8

1 reference

21 June 2017

Harry A Fozzard

9

1 reference

21 June 2017

language of work or name

English

0 references

publication date

6 October 2010

1 reference

21 June 2017

number of pages

13

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

21 June 2017

volume

285

1 reference

21 June 2017

issue

50

1 reference

21 June 2017

page(s)

39458-39470

1 reference

Structural basis for the coupling between activation and inactivation gates in K(+) channels

21 June 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Structural mechanism of C-type inactivation in K(+) channels

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

State-dependent trapping of flecainide in the cardiac sodium channel

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Neuromodulation of Na+ channels: an unexpected form of cellular plasticity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Molecular driving forces determining potassium channel slow inactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Probing the cavity of the slow inactivated conformation of shaker potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Cross talk between activation and slow inactivation gates of Shaker potassium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

New roles for a key glycine and its neighboring residue in potassium channel gating

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Tryptophan substitution of a putative D4S6 gating hinge alters slow inactivation in cardiac sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A conducting state with properties of a slow inactivated state in a shaker K(+) channel mutant

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Permeation of large tetra-alkylammonium cations through mutant and wild-type voltage-gated sodium channels as revealed by relief of block at high voltage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Enhanced slow inactivation by V445M: a sodium channel mutation associated with myotonia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Functional consequences of a decreased potassium affinity in a potassium channel pore. Ion interactions and C-type inactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Temperature and pressure dependence of Shaker K+ channel N- and C-type inactivation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Effect of alkali metal cations on slow inactivation of cardiac Na+ channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A mutation in segment I-S6 alters slow inactivation of sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Dynamic rearrangement of the outer mouth of a K+ channel during gating

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Interactions of the H5 pore region and hydroxylamine with N-type inactivation in the Shaker K+ channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

A mutation in the pore of the sodium channel alters gating

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Access and binding of local anesthetics in the closed sodium channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

The selectivity filter of the voltage-gated sodium channel is involved in channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Compound-specific Na+ channel pore conformational changes induced by local anaesthetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Closing and inactivation potentiate the cocaethylene inhibition of cardiac sodium channels by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.132886

Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2998134

KcsA crystal structure as framework for a molecular model of the Na(+) channel pore

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20926383

12 December 2020

inferred from PubMed ID database lookup

Energetics of pore opening in a voltage-gated K(+) channel

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20926383

12 December 2020

inferred from PubMed ID database lookup

Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20926383

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M110.132886

1 reference

21 June 2017

0 references

1 reference