(Q28583933)

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

microvasculature remodeling

3 February 2020

main subject

apoptotic process

0 references

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Mélanie Roy

2

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Sébastien Bonnet

5

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Caroline M Lambert

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Geneviève A Robitaille

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

publication date

24 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

published in

Cardiovascular Research

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

volume

88

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

issue

1

2 references

31 January 2017

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3 February 2020

page(s)

196-204

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

3 February 2020

cites work

1 reference

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On the Origin of Cancer Cells

21 January 2018

1 reference

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The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

21 January 2018

1 reference

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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

21 January 2018

1 reference

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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

21 January 2018

1 reference

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Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Cancer's molecular sweet tooth and the Warburg effect.

21 January 2018

1 reference

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Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Regulation of hexokinase binding to VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

21 January 2018

1 reference

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Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer

21 January 2018

1 reference

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Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

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Constitutively active glycogen synthase kinase-3beta gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

The glamour and gloom of glycogen synthase kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Targeted small-molecule inhibitors of protein kinase B as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Hypoxia and dehydroepiandrosterone in old age: a mouse survival study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

HIF-1alpha and STAT3 client proteins interacting with the cancer chaperone Hsp90: therapeutic considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVQ152

21 January 2018

Identifiers

DOI

10.1093/CVR/CVQ152

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20498255%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017