(Q28585518)

31 January 2017

title

Early mitochondrial dysfunction in long-lived Mclk1+/- mice (English)

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31 January 2017

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GOA release 2020-03-11

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Jérôme Lapointe

1

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31 January 2017

Siegfried Hekimi

series ordinal

2

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31 January 2017

language of work or name

English

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publication date

19 September 2008

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

283

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31 January 2017

issue

38

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31 January 2017

page(s)

26217–26227

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

31 January 2017

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7 April 2017

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A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans

7 April 2017

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29 September 2017

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29 September 2017

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Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

29 September 2017

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

29 September 2017

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Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans

29 September 2017

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The respiratory effects of stanniocalcin-1 (STC-1) on intact mitochondria and cells: STC-1 uncouples oxidative phosphorylation and its actions are modulated by nucleotide triphosphates

29 September 2017

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How genetic analysis tests theories of animal aging

29 September 2017

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Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans

29 September 2017

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Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress

29 September 2017

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Metabolism, ubiquinone synthesis, and longevity

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants

29 September 2017

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29 September 2017

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29 September 2017

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Oxidative damage and mitochondrial decay in aging

29 September 2017

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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

29 September 2017

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Superoxide radical and iron modulate aconitase activity in mammalian cells

29 September 2017

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Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

29 September 2017

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

29 September 2017

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Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase

29 September 2017

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Determination of life-span in Caenorhabditis elegans by four clock genes

3 June 2018

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Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Routes of electron transfer in beef heart cytochrome c oxidase: is there a unique pathway used by all reductants?

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

NADH oxidase activity of rat liver xanthine dehydrogenase and xanthine oxidase-contribution for damage mechanisms

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Biotin enhances ATP synthesis in pancreatic islets of the rat, resulting in reinforcement of glucose-induced insulin secretion

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers.

27 November 2018

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Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Rates of behavior and aging specified by mitochondrial function during development

27 November 2018

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Oxidative stress hypothesis of aging.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Modulation of mitochondrial function by hydrogen peroxide

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3258865

27 November 2018

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Quantitative resolution of succinate-cytochrome c reductase into succinate-ubiquinone and ubiquinol-cytochrome c reductases

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12 December 2020

Carboxyatractyloside-insensitive influx and efflux of adenine nucleotides in rat liver mitochondria

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12 December 2020

Assays of glutathione peroxidase

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Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

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12 December 2020

Transient reduction of metabolic rate by food restriction

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12 December 2020

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

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12 December 2020

Mitochondrial damage induced by conditions of oxidative stress

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12 December 2020

High oxidative damage levels in the longest-living rodent, the naked mole-rat

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12 December 2020