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Nkx2.2 regulates beta-cell function in the mature islet
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scholarly article
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stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
title
Nkx2.2 regulates beta-cell function in the mature islet
(English)
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
main subject
NK2 homeobox 2
1 reference
stated in
GOA release 2020-03-11
cell function
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author
Lori Sussel
series ordinal
2
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author name string
Michelle J. Doyle
series ordinal
1
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
language of work or name
English
0 references
publication date
1 August 2007
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
published in
Diabetes
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stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
volume
56
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stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
issue
8
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
page(s)
1999–2007
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
cites work
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Contextual interactions determine whether the Drosophila homeodomain protein, Vnd, acts as a repressor or activator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
17 March 2017
MafA is a key regulator of glucose-stimulated insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Minireview: transcriptional regulation in pancreatic development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
New insights into amino acid metabolism, beta-cell function and diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Transcriptional networks controlling pancreatic development and beta cell function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Gene expression cascades in pancreatic development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
29 September 2017
Distinct gene expression programs function in progenitor and mature islet cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
3 June 2018
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
27 November 2018
Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
27 November 2018
Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805073
retrieved
27 November 2018
Identifiers
DOI
10.2337/DB06-1766
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
PMC publication ID
2805073
0 references
PubMed publication ID
17456846
1 reference
stated in
PubMed
PubMed publication ID
17456846
retrieved
31 January 2017
ResearchGate publication ID
6372011
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