(Q28590672)

31 January 2017

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4 November 2019

title

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

Runt related transcription factor 3

4 November 2019

main subject

1 reference

Runt-related transcription factor 1

GOA release 2020-03-11

1 reference

Runt related transcription factor 2

GOA release 2020-03-11

1 reference

protein heterodimerization activity

GOA release 2020-03-11

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Jerónimo Bravo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

John H Bushweller

9

1 reference

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4 November 2019

author name string

Lina Zhang

1

2 references

31 January 2017

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4 November 2019

Zhe Li

2

2 references

31 January 2017

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4 November 2019

Jiangli Yan

3

2 references

31 January 2017

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4 November 2019

Padmanava Pradhan

4

2 references

31 January 2017

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4 November 2019

Takeshi Corpora

5

2 references

31 January 2017

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4 November 2019

Alan J Warren

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Nancy A Speck

10

1 reference

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4 November 2019

language of work or name

English

0 references

publication date

13 June 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 November 2019

published in

2 references

31 January 2017

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4 November 2019

volume

278

2 references

31 January 2017

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4 November 2019

issue

35

2 references

31 January 2017

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4 November 2019

page(s)

33097-33104

1 reference

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

4 November 2019

cites work

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

28 May 2017

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Cbfbeta interacts with Runx2 and has a critical role in bone development

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The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

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Causal relationship between the loss of RUNX3 expression and gastric cancer

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Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

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Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

28 May 2017

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Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

28 May 2017

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The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

28 May 2017

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The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp

28 May 2017

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DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending

28 May 2017

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Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta

28 May 2017

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The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding

28 May 2017

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Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta

28 May 2017

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Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

28 May 2017

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Thermodynamic stability of wild-type and mutant p53 core domain

28 May 2017

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Solution structure of core binding factor beta and map of the CBF alpha binding site

28 May 2017

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Anatomy of hot spots in protein interfaces

28 May 2017

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

28 May 2017

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Convergent solutions to binding at a protein-protein interface

28 May 2017

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

28 May 2017

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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

28 May 2017

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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

28 May 2017

1 reference

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Superadditive and subadditive effects of "hot spot" mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A

28 May 2017

1 reference

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

28 May 2017

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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

21 January 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

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Core-binding factor beta interacts with Runx2 and is required for skeletal development

21 January 2018

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The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

21 January 2018

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Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

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The Runt domain identifies a new family of heteromeric transcriptional regulators.

21 January 2018

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Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt

21 January 2018

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Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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DNA-binding by Ig-fold proteins

21 January 2018

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Functional mutagenesis of AML1/RUNX1 and PEBP2 beta/CBF beta define distinct, non-overlapping sites for DNA recognition and heterodimerization by the Runt domain

21 January 2018

1 reference

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Active-site sulfhydryl chemistry plays a major role in the misfolding of urea-denatured rhodanese

21 January 2018

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18 Systematic mutational analyses of protein-protein interfaces

21 January 2018

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CBF beta-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303972200

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12807883%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017