(Q28590845)

31 January 2017

title

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3 (English)

1 reference

GLI-Kruppel family member GLI2

31 January 2017

main subject

1 reference

GLI-Kruppel family member GLI3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Megan Bowers

1

1 reference

31 January 2017

Liane Eng

2

1 reference

31 January 2017

Zhimin Lao

3

1 reference

31 January 2017

Rowena K. Turnbull

4

1 reference

31 January 2017

Xiaozhong Bao

5

1 reference

31 January 2017

Elyn Riedel

6

1 reference

31 January 2017

Susan Mackem

7

1 reference

31 January 2017

Alexandra L. Joyner

8

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 October 2012

1 reference

31 January 2017

published in

Developmental Biology

1 reference

31 January 2017

volume

370

1 reference

31 January 2017

issue

1

1 reference

31 January 2017

page(s)

110–124

1 reference

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development

31 January 2017

cites work

1 reference

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Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

17 March 2017

1 reference

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The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

17 March 2017

1 reference

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Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling

17 March 2017

1 reference

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Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

17 March 2017

1 reference

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Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

17 March 2017

1 reference

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All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

A re-examination of proximodistal patterning during vertebrate limb development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Gli1 can rescue the in vivo function of Gli2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Generalized lacZ expression with the ROSA26 Cre reporter strain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Sonic hedgehog mediates the polarizing activity of the ZPA

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Hedgehog signaling in development and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

How do we get a perfect complement of digits?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Specification of cell fate along the proximal-distal axis in the developing chick limb bud.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Hox gene expression in limbs: colinearity by opposite regulatory controls.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Expression profile of Gli family members and Shh in normal and mutant mouse limb development.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

A staging system for mouse limb development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Integration of growth and specification in chick wing digit-patterning.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Genetic interaction of Gli3 and Alx4 during limb development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Expression pattern of Irx1 and Irx2 during mouse digit development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3432687

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development

27 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

Carboxy-terminally truncated Gli3 proteins associate with Smads

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

The number of polarizing region cells required to specify additional digits in the developing chick wing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

Positional signalling and specification of digits in chick limb morphogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2012.07.017

Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway

7 January 2021

1 reference

https://pubmed.ncbi.nlm.nih.gov/22841643

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YDBIO.2012.07.017

1 reference

1 reference

1 reference

1 reference