Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q28609172)
Watch
English
Botulinum and tetanus neurotoxins: structure, function and therapeutic utility
scientific journal article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
review article
1 reference
stated in
Europe PubMed Central
title
Botulinum and tetanus neurotoxins: structure, function and therapeutic utility
(English)
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
author
Kathryn Turton
0 references
author name string
Kathryn Turton
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
John A. Chaddock
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
K. Ravi Acharya
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
publication date
1 November 2002
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
published in
Trends in Biochemical Sciences
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
volume
27
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
page(s)
552–558
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
issue
11
1 reference
stated in
PubMed
PubMed ID
12417130
retrieved
3 February 2017
cites work
Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequence homology and structural analysis of the clostridial neurotoxins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of botulinum neurotoxin type A and implications for toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the receptor binding fragment HC of tetanus neurotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based sequence alignment for the beta-trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How do tetanus and botulinum toxins bind to neuronal membranes?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bacterial protein toxins penetrate cells via a four-step mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The N-terminal half of the heavy chain of botulinum type A neurotoxin forms channels in planar phospholipid bilayers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gating and permeability of ion channels produced by botulinum toxin types A and E in PC12 cell membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synaptic vesicle docking and fusion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How botulinum and tetanus neurotoxins block neurotransmitter release.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tetanus toxin and spinal inhibition.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ion-conducting channels produced by botulinum toxin in planar lipid membranes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spectroscopic analysis of pH-induced changes in the molecular features of type A botulinum neurotoxin light chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine phosphorylation modulates the activity of clostridial neurotoxins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural stabilization of botulinum neurotoxins by tyrosine phosphorylation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clostridial neurotoxin-insensitive vesicular SNAREs in exocytosis and endocytosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SNARE motif and neurotoxins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of zinc in the structure and toxic activity of botulinum neurotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of zinc binding in type A botulinum neurotoxin light chain's toxic structure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of zinc binding in the biological activity of botulinum toxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metal substitution of tetanus neurotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis of the action of thermolysin and related zinc peptidases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and purification of the light chain of botulinum neurotoxin A: a single mutation abolishes its cleavage of SNAP-25 and neurotoxicity after reconstitution with the heavy chain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exocytosis requires asymmetry in the central layer of the SNARE complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Uses of botulinum toxin injection in medicine today
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Botulinum toxin A for axillary hyperhidrosis (excessive sweating).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Botulinum toxin type A as a migraine preventive treatment. For the BOTOX Migraine Clinical Research Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Botulinum neurotoxin serotype C: a novel effective botulinum toxin therapy in human.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the characteristics that underlie botulinum toxin potency: implications for designing novel drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant derivatives of clostridial neurotoxins as delivery vehicles for proteins and small organic molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemotherapeutic tumour targeting using clostridial spores
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0968-0004%2802%2902177-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0968-0004(02)02177-1
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1925056
OpenCitations bibliographic resource ID
1925056
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1925056
PubMed ID
12417130
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1925056
ResearchGate publication ID
11048938
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit