(Q28609428)

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A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters

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PubMed publication ID

3 February 2017

A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters (English)

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

1 reference

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author name string

David Robertson

2

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

Maureen K Hahn

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

Randy D Blakely

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

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publication date

1 June 2003

1 reference

PubMed publication ID

3 February 2017

Journal of Neuroscience

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

23

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

11

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

4470-4478

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of serotonin transporter and its functional consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pentameric assembly of a neuronal glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trafficking checkpoint controls GABA(B) receptor heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal norepinephrine transporter in experimental heart failure: evidence for a posttranscriptional downregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological genomics of antidepressant targets: keeping the periphery in mind.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial beta-adrenergic desensitization and neuronal norepinephrine uptake function in idiopathic dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE UPTAKE OF NORADRENALINE BY THE ISOLATED PERFUSED RAT HEART.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3Hnisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catecholamine release and arrhythmias in acute myocardial ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The extent of neuronal re-uptake of 3H-noradrenaline in isolated vasa deferentia and atria of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The catecholamine hypothesis of affective disorders: a review of supporting evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiarrhythmic action of amitriptyline on arrhythmias associated with myocardial infarction in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Norepinephrine kinetics in essential hypertension. Defective neuronal uptake of norepinephrine in some patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for reduction of norepinephrine uptake sites in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type-specific expression of catecholamine transporters in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo dynamics of norepinephrine release-reuptake in multiple terminal field regions of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of noradrenaline in depression: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible existence of quaternary structure in the high-affinity serotonin transport complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The family of Na+/Cl- neurotransmitter transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-11-04470.2003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

PubMed publication ID

2 references

PubMed publication ID

3 February 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

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