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Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
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scholarly article
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
title
Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
(English)
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
main subject
lymphocyte
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B-cell
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based on heuristic
inferred from title
author name string
S. L. Harmer
series ordinal
1
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PubMed
PubMed ID
9199344
retrieved
3 February 2017
A. L. DeFranco
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2
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stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
language of work or name
English
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publication date
1 July 1997
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PubMed
PubMed ID
9199344
retrieved
3 February 2017
published in
Molecular and Cellular Biology
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
volume
17
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
page(s)
4087–4095
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
issue
7
1 reference
stated in
PubMed
PubMed ID
9199344
retrieved
3 February 2017
cites work
A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
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PubMed Central
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The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
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PubMed Central
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17 March 2017
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2
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17 March 2017
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
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PubMed Central
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17 March 2017
Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2
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Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase
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17 March 2017
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain
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PubMed Central
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17 March 2017
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
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17 March 2017
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
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PubMed Central
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17 March 2017
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
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PubMed Central
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17 March 2017
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins
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PubMed Central
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17 March 2017
B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins
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17 March 2017
B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein
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PubMed Central
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17 March 2017
Crystal structure of the mammalian Grb2 adaptor
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PubMed Central
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17 March 2017
Differential interactions of human Sos1 and Sos2 with Grb2
1 reference
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PubMed Central
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17 March 2017
Protein modules and signalling networks
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PubMed Central
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17 March 2017
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS
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PubMed Central
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17 March 2017
Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions
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17 March 2017
Syk tyrosine kinase required for mouse viability and B-cell development
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PubMed Central
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17 March 2017
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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17 March 2017
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
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PubMed Central
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17 March 2017
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
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17 March 2017
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
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PubMed Central
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17 March 2017
pEF-BOS, a powerful mammalian expression vector
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7 April 2017
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
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PubMed Central
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7 April 2017
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
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PubMed Central
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7 April 2017
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav
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PubMed Central
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7 April 2017
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
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7 April 2017
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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7 April 2017
Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation
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PubMed Central
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3 June 2018
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins
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3 June 2018
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires
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3 June 2018
Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway.
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PubMed Central
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3 June 2018
Activators and effectors of ras p21 proteins
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PubMed Central
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3 June 2018
Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways
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PubMed Central
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3 June 2018
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.
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PubMed Central
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3 June 2018
Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
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PubMed Central
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3 June 2018
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit
1 reference
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PubMed Central
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3 June 2018
Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes
1 reference
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PubMed Central
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3 June 2018
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line
1 reference
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PubMed Central
reference URL
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3 June 2018
A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
The Grb2 adaptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Transmembrane signaling by antigen receptors of B and T lymphocytes
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PubMed Central
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3 June 2018
Signal transduction in T lymphocytes using a conditional allele of Sos
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Protein tyrosine kinases in the initiation of antigen receptor signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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3 June 2018
B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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27 November 2018
Signal transduction. How receptors turn Ras on.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
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27 November 2018
Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232262
retrieved
27 November 2018
Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9199344
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9199344
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9199344
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.17.7.4087
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2364369
OpenCitations bibliographic resource ID
2364369
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2364369
PMCID
232262
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2364369
PubMed ID
9199344
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2364369
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