(Q28749496)

English

The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway

scientific article (publication date: 13 November 2009)

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scholarly article

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The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway (English)

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author name string

Maria Marjorette O Peña

1

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Sandra P Melo

2

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Yang-Yang Xing

3

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Kenneth White

4

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Karen W Barbour

5

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Franklin G Berger

6

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language of work or name

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publication date

13 November 2009

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Journal of Biological Chemistry

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284

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46

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31597-607

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2797230/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Function and structure of inherently disordered proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Ubiquitin-independent degradation of proteins by the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Clustal W and Clustal X version 2.0

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

A practical overview of protein disorder prediction methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

The catalytic mechanism and structure of thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Atomic structure of thymidylate synthase: target for rational drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

16 March 2017

Sequence complexity of disordered protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

7 April 2017

The ubiquitin-proteasome pathway: on protein death and cell life

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

7 April 2017

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Ubiquitin-independent degradation of hepatitis C virus F protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

The unfoldomics decade: an update on intrinsically disordered proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Tuning the strength of a bacterial N-end rule degradation signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Ubiquitin-independent- versus ubiquitin-dependent proteasomal degradation of the c-Fos and Fra-1 transcription factors: is there a unique answer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Proteasome substrate degradation requires association plus extended peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Impact of the N-terminal amino acid on targeted protein degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Processed N-termini of mature proteins in higher eukaryotes and their major contribution to dynamic proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Stable inhibition of human thymidylate synthase expression following retroviral introduction of an siRNA gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Protein N-terminal methionine excision.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Structural determinants for the intracellular degradation of human thymidylate synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

c-Fos Proto-Oncoprotein Is Degraded by the Proteasome Independently of Its Own Ubiquitinylation In Vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Inhibition of thymidylate synthase activity by antisense oligodeoxynucleotide and possible role in thymineless treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Nalpha -terminal acetylation of eukaryotic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

A survey of left-handed polyproline II helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Purification and NH2-terminal amino acid sequence of human thymidylate synthase in an overproducing transformant of mouse FM3A cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Altered turnover of allelic variants of hypoxanthine phosphoribosyltransferase is associated with N-terminal amino acid sequence variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Thymidylate synthase-deficient Chinese hamster cells: a selection system for human chromosome 18 and experimental system for the study of thymidylate synthase regulation and fragile X expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2797230

3 June 2018

Proteasomes begin ornithine decarboxylase digestion at the C terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

Evolutionary rate heterogeneity in proteins with long disordered regions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

The proteomics of N-terminal methionine cleavage.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

Extent of N-terminal modifications in cytosolic proteins from eukaryotes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

An unstructured initiation site is required for efficient proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038455

21 January 2018

Thymidylate synthase as a chemotherapeutic drug target: where are we after fifty years?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19797058

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of proteins with acetylated amino termini by the ubiquitin system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19797058

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting Protein Disorder for N-, C-, and Internal Regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19797058

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.038455

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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