(Q28817181)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

main subject

Chagas disease

0 references

African trypanosomiasis

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Elmarie Myburgh

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jeremy C. Mottram

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Frederick S Buckner

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Shilpi Khare

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Advait S Nagle

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Agnes Biggart

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Yin H Lai

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Fang Liang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Lauren C Davis

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

S Whitney Barnes

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Mu-Yun Gao

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

J Robert Gillespie

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Xianzhong Liu

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jocelyn L Tan

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Monique Stinson

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ianne C Rivera

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jaime Ballard

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Vince Yeh

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Todd Groessl

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Glenn Federe

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Hazel X Y Koh

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

John D Venable

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Badry Bursulaya

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Michael Shapiro

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Pranab K Mishra

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ansgar Brock

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Srinivasa P S Rao

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ben G Wen

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

John R Walker

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Tove Tuntland

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Valentina Molteni

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Richard J Glynne

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Frantisek Supek

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Glen Spraggon

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

language of work or name

English

0 references

publication date

8 August 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

537

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

7619

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

229-233

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

20 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Combating the next lethal epidemic

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Chagas disease: an overview of clinical and epidemiological aspects

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

GeneDB--an annotation database for pathogens

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

The genome of the kinetoplastid parasite, Leishmania major

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

The structure of the mammalian 20S proteasome at 2.75 A resolution

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Comparative genomics of trypanosomatid parasitic protozoa

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Infectious diseases. Overcoming neglect of kinetoplastid diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

An update on pharmacotherapy for leishmaniasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Chagas disease drug discovery: toward a new era.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Towards a paradigm shift in the treatment of chronic Chagas disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Leishmaniasis: clinical syndromes and treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Research priorities for Chagas disease, human African trypanosomiasis and leishmaniasis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Antitrypanosomal therapy for chronic Chagas' disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Effect of noncompetitive proteasome inhibition on bortezomib resistance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Chagas disease: 100 years after its discovery. A systemic review

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Recent advances in physicochemical and ADMET profiling in drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

The isolation and characterization of murine macrophages

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Animal models for the analysis of immune responses to leishmaniasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Nanodisk-associated amphotericin B clears Leishmania major cutaneous infection in susceptible BALB/c mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

An efficient rapid system for profiling the cellular activities of molecular libraries.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Chemical blockage of the proteasome inhibitory function of bortezomib: impact on tumor cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro data.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161665

Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE19339

Stable transformation of Trypanosoma cruzi: inactivation of the PUB12.5 polyubiquitin gene by targeted gene disruption

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE19339

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19339

Purification of the eukaryotic 20S proteasome

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27501246

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE19339

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 March 2020

1036903066

0 references

OpenCitations bibliographic resource ID

3513955

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27501246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

27501246

1 reference