(Q28975212)

21 March 2017

title

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site (English)

1 reference

Mycobacterium tuberculosis

21 March 2017

main subject

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Bryan T Mott

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Adam Yasgar

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Craig J. Thomas

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Monica Kasbekar

1

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Marko Hyvönen

5

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Chris Abell

7

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Helena I M Boshoff

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Clifton E Barry

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

5 July 2016

1 reference

Proceedings of the National Academy of Sciences of the United States of America

21 March 2017

published in

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

113

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

27

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

7503-7508

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis

9 June 2020

cites work

1 reference

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A Noncompetitive Inhibitor for Mycobacterium tuberculosis ’s Class IIa Fructose 1,6-Bisphosphate Aldolase

23 March 2017

1 reference

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Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis

23 March 2017

1 reference

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Fumarase: a paradigm of dual targeting and dual localized functions

23 March 2017

1 reference

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The original Michaelis constant: translation of the 1913 Michaelis-Menten paper

23 March 2017

1 reference

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Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response

23 March 2017

1 reference

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Compound Management for Quantitative High-Throughput Screening

23 March 2017

1 reference

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Regulation of gene expression by a metabolic enzyme

23 March 2017

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Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

23 March 2017

1 reference

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X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation

23 March 2017

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

23 March 2017

1 reference

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Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli

23 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity

23 March 2017

1 reference

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Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

3 June 2018

1 reference

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Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

3 June 2018

1 reference

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Moonlighting is mainstream: paradigm adjustment required

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

The NIH Molecular Libraries Program: identifying chemical probes for new medicines

3 June 2018

1 reference

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Moonlighting proteins: an intriguing mode of multitasking

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Moonlighting proteins--an update.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Fluorescence spectroscopic profiling of compound libraries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

3 June 2018

1 reference

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Multifaceted roles of glycolytic enzymes.

3 June 2018

1 reference

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Tuberculosis - metabolism and respiration in the absence of growth

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Studies on fumarase. 4. The effects of inhibitors on fumarase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941444

Studies on fumarase. III. The effect of temperature

3 June 2018

1 reference

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Studies on fumarase. II. The effects of inorganic anions on fumarase activity

3 June 2018

1 reference

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The Hill equation revisited: uses and misuses.

3 June 2018

1 reference

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The multisubunit active site of fumarase C from Escherichia coli

3 June 2018

1 reference

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The fumarase genes of Escherichia coli: location of the fumB gene and discovery of a new gene (fumC).

3 June 2018

1 reference

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A Robot-based platform to measure multiple enzyme activities in Arabidopsis using a set of cycling assays: comparison of changes of enzyme activities and transcript levels during diurnal cycles and in prolonged darkness

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1600630113

Pig heart fumarase contains two distinct substrate-binding sites differing in affinity

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325754

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1600630113

2 references

21 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325754%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

2 references

21 March 2017