(Q29395121)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

review article

1 reference

title

All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1 reference

Philip Seeman

1

2 references

14 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

publication date

1 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

number of pages

15

1 reference

CNS Neuroscience & Therapeutics

inferred from page(s)

published in

2 references

14 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

17

2 references

14 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

2

2 references

14 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

118-132

2 references

14 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

Provocative tests with psychostimulant drugs in schizophrenia

5 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Stimulant psychosis: systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

New dopamine receptor, D2(Longer), with unique TG splice site, in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Targeting the dopamine D2 receptor in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Antiparkinson therapeutic potencies correlate with their affinities at dopamine D2(High) receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Brain receptors for antipsychotic drugs and dopamine: direct binding assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Antipsychotic drug doses and neuroleptic/dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Cloning and expression of a rat D2 dopamine receptor cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Multiple receptors for dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine receptors and the dopamine hypothesis of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine receptor parameters detected by [3H]spiperone depend on tissue concentration: analysis and examples

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine D2 receptors as treatment targets in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Bimodal Distribution of Dopamine Receptor Densities in Brains of Schizophrenics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Psychosis pathways converge via D2high dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Increased dopamine D2High receptors in rats reared in social isolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine D2(High) receptors on intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Neonatal ventral hippocampus lesion leads to reductions in nerve growth factor inducible-B mRNA in the prefrontal cortex and increased amphetamine response in the nucleus accumbens and dorsal striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Cocaine self-administration produces a persistent increase in dopamine D2 High receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Increase of dopamine D2(High) receptors in the striatum of rats sensitized to caffeine motor effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Increased proportion of high-affinity dopamine D2 receptors in rats with excitotoxic damage of the entorhinal cortex, an animal model of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Rats with persistently high exploratory activity have both higher extracellular dopamine levels and higher proportion of D(2) (High) receptors in the striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Dopamine D2High receptors measured ex vivo are elevated in amphetamine-sensitized animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Effects of pertussis toxin on D2-dopamine receptor in rat striatum: evidence for coupling of Ni regulatory protein with D2-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Striatal D2 receptor binding as a marker of prognosis and outcome in untreated first-episode psychosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Schizophrenia model of elevated D2(High) receptors: haloperidol reverses the amphetamine-induced elevation in dopamine D2(High).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Historical development of the dopamine hypothesis of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Evidence for onset of antipsychotic effects within the first 24 hours of treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Early antipsychotic response to resumption of neuroleptics in drug-free chronic schizophrenic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Time course of antipsychotic effects of neuroleptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Time course and biologic correlates of treatment response in first-episode schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Elevation of brain neuroleptic/dopamine receptors in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Neuroleptic-induced supersensitivity psychosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Severe cases of neuroleptic-induced supersensitivity psychosis. Diagnostic criteria for the disorder and its treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Schizophrenia as dopamine-deficiency disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

A rating scale for psychotic symptoms (RSPS) part I: theoretical principles and subscale 1: perception symptoms (illusions and hallucinations).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Atypical antipsychotics: CATIE study, drug-induced movement disorder and resulting iatrogenic psychiatric-like symptoms, supersensitivity rebound psychosis and withdrawal discontinuation syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00162.X

Atypical antipsychotics: mechanism of action.

21 January 2018

1 reference

12 December 2020

The brain's dopamine receptor: labeling with (3H) dopamine and (3H) haloperidol

1 reference

12 December 2020

[Therapeutic method derived from hiberno-therapy in excitation and agitation states]

1 reference

12 December 2020

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4

1 reference

12 December 2020

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors

1 reference

12 December 2020

DIFFERENT TYPES OF SYMPATHOMIMETIC ALPHA-RECEPTORS

1 reference

12 December 2020

MECHANISM OF ACTION OF PSYCHOMOTOR STIMULANT DRUGS. SIGNIFICANCE OF DOPAMINE IN LOCOMOTOR STIMULANT ACTION.

1 reference

12 December 2020

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.

1 reference

12 December 2020

Time course for antipsychotic treatment response in first-episode schizophrenia

1 reference

12 December 2020

Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia

1 reference

12 December 2020

Elevated dopamine D2High receptors in alpha-1b-adrenoceptor knockout supersensitive mice

1 reference

12 December 2020

Glutamate and dopamine components in schizophrenia.

1 reference

12 December 2020

Kinetic properties of the in vivo accumulation of 3H-(-)-N-n-propylnorapomorphine in mouse brain

1 reference

12 December 2020

Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes.

1 reference

12 December 2020

Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system

1 reference

12 December 2020

Relation of clinical symptoms to apomorphine-stimulated growth hormone release in mood-incongruent psychotic patients

1 reference

12 December 2020

Evidence of Brain Dopamine Deficiency in Schizophrenia

1 reference

12 December 2020

The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs

1 reference

12 December 2020

Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization

1 reference

12 December 2020

Dopamine receptor binding on intact cells. Absence of a high-affinity agonist-receptor binding state

1 reference

12 December 2020

No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.

1 reference

12 December 2020

Psychotolysis with haloperidol. Rapid control of the acutely disturbed psychotic patient

1 reference

12 December 2020

Rapid treatment of acute psychosis

1 reference

12 December 2020

Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes

1 reference

12 December 2020

Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia

1 reference

12 December 2020

10.1111/J.1755-5949.2010.00162.X

Identifiers

DOI

3 references

14 April 2017

Consolidated OpenCitations Corpus – April 2017

2471398

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

2471398

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20560996%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

20560996

2 references

Consolidated OpenCitations Corpus – April 2017

2471398