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How eukaryotic transcriptional activators work
scientific article (publication date: 20 October 1988)
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How eukaryotic transcriptional activators work
(English)
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Ptashne M
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publication date
20 October 1988
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published in
Nature
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335
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683-9
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6192
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30 April 2017
cites work
Gene regulation by proteins acting nearby and at a distance
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Mutant lambda phage repressor with a specific defect in its positive control function
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Repressor structure and the mechanism of positive control
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Turning lambda Cro into a transcriptional activator
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7 January 2021
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A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
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7 January 2021
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Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein
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7 January 2021
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A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site
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7 January 2021
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Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.
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7 January 2021
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GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast
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Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
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7 January 2021
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Deletion analysis of GAL4 defines two transcriptional activating segments
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7 January 2021
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Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein
1 reference
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7 January 2021
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Mutants of GAL4 protein altered in an activation function
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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Negative effect of the transcriptional activator GAL4
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7 January 2021
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A new class of yeast transcriptional activators
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7 January 2021
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Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit
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7 January 2021
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DNA-bound Fos proteins activate transcription in yeast
1 reference
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7 January 2021
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A yeast gene that is essential for release from glucose repression encodes a protein kinase
1 reference
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7 January 2021
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Activation of transcription factor IIIC by the adenovirus E1A protein.
1 reference
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7 January 2021
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Signal transduction and transcriptional regulation by glucocorticoid receptor-LexA fusion proteins
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7 January 2021
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The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
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7 January 2021
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Mammalian glucocorticoid receptor derivatives enhance transcription in yeast
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7 January 2021
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The human oestrogen receptor functions in yeast
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7 January 2021
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GAL4 activates transcription in Drosophila.
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7 January 2021
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Yeast activators stimulate plant gene expression
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7 January 2021
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GAL4 activates gene expression in mammalian cells
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7 January 2021
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The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator
1 reference
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7 January 2021
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The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.
1 reference
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7 January 2021
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Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
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7 January 2021
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Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.
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7 January 2021
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Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation
1 reference
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence
1 reference
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins
1 reference
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7 January 2021
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Regulation of inducible and tissue-specific gene expression
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7 January 2021
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Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms
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7 January 2021
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Redundancy of information in enhancers as a principle of mammalian transcription control
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7 January 2021
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The SV40 enhancer contains two distinct levels of organization
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7 January 2021
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The SV40 enhancer is composed of multiple functional elements that can compensate for one another
1 reference
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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inferred from DOI database lookup
Cooperative DNA binding of the yeast transcriptional activator GAL4.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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inferred from DOI database lookup
GAL4 derivatives function alone and synergistically with mammalian activators in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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inferred from DOI database lookup
An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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Acid blobs and negative noodles
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Function of a yeast TATA element-binding protein in a mammalian transcription system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A yeast activity can substitute for the HeLa cell TATA box factor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Drosophila Adh: A promoter element expands the tissue specificity of an enhancer
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of positive and negative regulatory proteins in the galactose regulon of yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of GAL4 and GAL80 gene regulatory proteins in vitro
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of activator binding sites in transcriptional control of the divergently transcribed nifF and nifLA promoters from Klebsiella pneumoniae
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Initiation of transcription at the bacterial glnAp2 promoter by purified E. coli components is facilitated by enhancers.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homologous interactions of lambda repressor and lambda Cro with the lambda operator
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA loops induced by cooperative binding of lambda repressor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific DNA binding of GAL4, a positive regulatory protein of yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific protein binding to far upstream activating sequences in polymerase II promoters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F335683A0
retrieved
7 January 2021
based on heuristic
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On the attribution and additivity of binding energies
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
based on heuristic
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A repressor heterodimer binds to a chimeric operator
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F335683A0
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7 January 2021
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Identifiers
DOI
10.1038/335683A0
2 references
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PubMed
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=3050531
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3593031
Dimensions Publication ID
1023826634
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24 November 2022
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OpenCitations bibliographic resource ID
3593031
1 reference
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Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3593031
PubMed ID
3050531
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=3050531
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3593031
Springer Nature article ID
10.1038/335683a0
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