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(Q29793974)
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GEN1 Holliday junction resolvase homolog CELE_T12A2.8
Protein found in Caenorhabditis elegans
GEN1 Holliday junction resolvase homolog
gen-1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q22418
part of
XPG/Rad2 endonuclease
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
PIN-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
5'-3' exonuclease, C-terminal domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
XPG N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
XPG-I domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Helix-hairpin-helix motif, class 2, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Caenorhabditis elegans
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q22418
encoded by
gen-1
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q22418
molecular function
DNA binding
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IEA
catalytic activity
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IEA
nuclease activity
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IEA
crossover junction endodeoxyribonuclease activity
determination method
IDA
1 reference
retrieved
16 July 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IDA
four-way junction DNA binding
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
DNA binding
determination method
IBA
IEA
2 references
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IEA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
double-stranded DNA binding
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
single-stranded DNA binding
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
single-stranded DNA 3'-5' exodeoxyribonuclease activity
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
double-stranded DNA 3'-5' exodeoxyribonuclease activity
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
crossover junction endodeoxyribonuclease activity
determination method
IBA
IDA
2 references
retrieved
1 January 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IBA
5'-flap endonuclease activity
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IBA
single-stranded DNA 5'-3' exodeoxyribonuclease activity
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
flap endonuclease activity
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IBA
double-stranded DNA 5'-3' exodeoxyribonuclease activity
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
5'-3' exodeoxyribonuclease activity
determination method
IBA
1 reference
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IBA
cell component
nucleus
determination method
ISS
1 reference
retrieved
1 January 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
ISS
cytoplasm
determination method
ISS
1 reference
retrieved
1 January 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
ISS
biological process
double-strand break repair via homologous recombination
determination method
IMP
1 reference
retrieved
16 July 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IMP
DNA repair
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IEA
intrinsic apoptotic signaling pathway in response to DNA damage
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IMP
negative regulation of nematode larval development
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline
GOA
curator
UniProt
UniProt protein ID
Q22418
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IMP
nucleic acid phosphodiester bond hydrolysis
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IEA
double-strand break repair via homologous recombination
determination method
IBA
IMP
2 references
retrieved
1 January 2018
stated in
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IMP
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q22418
determination method
IBA
DNA catabolic process, endonucleolytic
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
DNA catabolic process, exonucleolytic
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
regulation of centrosome duplication
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
UV-damage excision repair
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
resolution of recombination intermediates
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
resolution of mitotic recombination intermediates
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
positive regulation of mitotic cell cycle spindle assembly checkpoint
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q22418&geneProductId=UniProtKB:Q22418
determination method
IBA
has part(s)
XPG-I domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
Helix-hairpin-helix motif, class 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
XPG N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q22418
Identifiers
RefSeq protein ID
NP_498361
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
175885
UniProt protein ID
Q22418
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q22418
Ensembl protein ID
T12A2.8.1
1 reference
stated in
ensembl Release 106
Ensembl protein ID
T12A2.8.1
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