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Sex-determining protein fem-1 CELE_F35D6.1
protein found in Caenorhabditis elegans
fem-1
Sex-determining protein fem-1
In more languages
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Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P17221
part of
Ankyrin repeat-containing domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P17221
Tetratricopeptide-like helical domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P17221
Ankyrin repeat-containing domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Ankyrin repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Caenorhabditis elegans
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P17221
encoded by
fem-1
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P17221
molecular function
protein binding
determination method
IPI
5 references
retrieved
1 January 2018
stated in
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
retrieved
1 January 2018
stated in
The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
retrieved
1 January 2018
stated in
The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
retrieved
1 January 2018
stated in
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
retrieved
1 January 2018
stated in
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
protein phosphatase binding
determination method
IPI
1 reference
retrieved
1 January 2018
stated in
Structural Insight into Caenorhabditis elegans Sex-determining Protein FEM-2
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
cell component
cytoplasm
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IEA
Cul2-RING ubiquitin ligase complex
determination method
IPI
1 reference
retrieved
1 January 2018
stated in
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IPI
protein-containing complex
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
Structural Insight into Caenorhabditis elegans Sex-determining Protein FEM-2
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IMP
biological process
multicellular organism development
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IEA
regulation of gene expression
determination method
IGI
1 reference
retrieved
1 January 2018
stated in
ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IGI
protein ubiquitination
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IEA
male germ-line sex determination
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IMP
male somatic sex determination
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IMP
transcription factor catabolic process
determination method
IDA
1 reference
retrieved
1 January 2018
stated in
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IDA
masculinization of hermaphroditic germ-line
determination method
IMP
1 reference
retrieved
1 January 2018
stated in
A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IMP
regulation of germ cell proliferation
determination method
IGI
1 reference
retrieved
1 January 2018
stated in
ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline.
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IGI
sex differentiation
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IEA
cell differentiation
determination method
IEA
1 reference
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P17221
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17221
determination method
IEA
has part(s)
ankyrin repeat-containing domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P17221
ankyrin repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P17221
Identifiers
RefSeq protein ID
NP_500824
1 reference
stated in
NCBI Gene
retrieved
14 December 2018
Entrez Gene ID
177335
NP_500825
1 reference
stated in
NCBI Gene
retrieved
14 December 2018
Entrez Gene ID
177335
UniProt protein ID
P17221
1 reference
stated in
UniProt
retrieved
5 December 2018
UniProt protein ID
P17221
Ensembl protein ID
F35D6.1a
1 reference
stated in
ensembl Release 96
Ensembl protein ID
F35D6.1a
F35D6.1b
1 reference
stated in
ensembl Release 96
Ensembl protein ID
F35D6.1b
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