(Q29812172)

Frizzled cysteine-rich domain superfamily

1 reference

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.16.5

2 October 2019

hierarchical database ID heuristic

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

1 reference

1 January 2018

protein binding

1 reference

8 April 2019

Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

Wnt-protein binding

1 reference

16 July 2018

Ligand receptor interactions in the Wnt signaling pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

Wnt-activated receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

3 references

8 April 2019

8 April 2019

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

cell component

endosome

1 reference

8 April 2019

Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

integral component of plasma membrane

frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

integral component of membrane

Frizzled-suc2 fusion gene studies in Saccharomyces cerevisiae

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Molecular structure of frizzled, a Drosophila tissue polarity gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Drosophila melanogaster G protein-coupled receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

integral component of membrane

Frizzled-suc2 fusion gene studies in Saccharomyces cerevisiae

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Molecular structure of frizzled, a Drosophila tissue polarity gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

establishment of planar polarity

biological process

Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

establishment of imaginal disc-derived wing hair orientation

Planar polarity: photoreceptors on a high fat diet

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

morphogenesis of a polarized epithelium

IEP

1 reference

8 April 2019

Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

compound eye morphogenesis

1 reference

8 April 2019

Analysis of micro- and nano-structures of the corneal surface of Drosophila and its mutants by atomic force microscopy and optical diffraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

homophilic cell adhesion via plasma membrane adhesion molecules

1 reference

8 April 2019

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment or maintenance of cell polarity

1 reference

8 April 2019

A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment of tissue polarity

1 reference

10 September 2018

The polarising role of cell adhesion molecules in early development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

border follicle cell migration

1 reference

8 April 2019

The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

segment polarity determination

1 reference

8 April 2019

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

salivary gland morphogenesis

1 reference

8 April 2019

Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

R3/R4 cell fate commitment

The polarising role of cell adhesion molecules in early development

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

10 September 2018

Frizzled receptors signal through G proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

heart development

1 reference

8 April 2019

Control of cardiac development by an evolutionarily conserved transcriptional network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

asymmetric cell division

1 reference

8 April 2019

Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

ommatidial rotation

sensory organ precursor cell fate determination

1 reference

8 April 2019

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment of cell polarity

1 reference

8 April 2019

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

regulation of actin filament bundle assembly

1 reference

8 April 2019

Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

regulation of tube length, open tracheal system

1 reference

8 April 2019

Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

regulation of hemocyte proliferation

1 reference

8 April 2019

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

chitin-based larval cuticle pattern formation

1 reference

8 April 2019

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

imaginal disc-derived wing hair organization

1 reference

8 April 2019

Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

imaginal disc-derived wing hair site selection

1 reference

8 April 2019

The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

non-canonical Wnt signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment of ommatidial planar polarity

A three-tiered mechanism for regulation of planar cell polarity.

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment of epithelial cell apical/basal polarity

1 reference

8 April 2019

Fidelity in planar cell polarity signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

negative regulation of Notch signaling pathway

1 reference

14 January 2019

Planar cell polarity controls directional Notch signaling in the Drosophila leg.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

positive regulation of axon extension

1 reference

8 April 2019

The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

axon extension

1 reference

8 April 2019

A signaling network for patterning of neuronal connectivity in the Drosophila brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

canonical Wnt signaling pathway

1 reference

16 July 2018

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18537&geneProductId=UniProtKB:P18537

Wnt signaling pathway, planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

1 reference

8 April 2019

positive regulation of axon guidance

1 reference

8 April 2019

The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

establishment of imaginal disc-derived wing hair orientation

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

8 April 2019

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

R3/R4 cell fate commitment

IEP

1 reference

8 April 2019

Frizzled receptors signal through G proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18537

Frizzled/Smoothened, transmembrane domain

has part(s)

1 reference

GPCR, family 2-like

1 reference

frizzled domain

1 reference

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9.A.14.16.5

2 references

Transporter Classification database

13 March 2020

Transporter Classification database