(Q29812416)

http://www.ebi.ac.uk/interpro/protein/Q8MUJ1

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

signaling receptor binding

1 reference

8 April 2019

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

tumor necrosis factor receptor binding

3 references

3 references

8 April 2019

Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

intracellular anatomical structure

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8MUJ1&geneProductId=UniProtKB:Q8MUJ1

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

Bendless modulates JNK-mediated cell death and migration in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

2 references

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

spanning component of plasma membrane

1 reference

8 April 2019

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

ISM

biological process

immune system process

1 reference

8 April 2019

5 references

8 April 2019

Apoptosis-an introduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

regulation of signaling receptor activity

IDA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

Neuronal programmed cell death induces glial cell division in the adult Drosophila brain.

glial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

melanization defense response

1 reference

8 April 2019

Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

engulfment of apoptotic cell

1 reference

8 April 2019

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

Drosophila eiger mutants are sensitive to extracellular pathogens

innate immune response

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

asymmetric protein localization involved in cell fate determination

1 reference

8 April 2019

Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

apical protein localization

1 reference

8 April 2019

Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

neuron cellular homeostasis

1 reference

8 April 2019

Glial-derived prodegenerative signaling in the Drosophila neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

extrinsic apoptotic signaling pathway

IGI

1 reference

8 April 2019

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

negative regulation of neuromuscular synaptic transmission

1 reference

8 April 2019

Glial-derived prodegenerative signaling in the Drosophila neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

positive regulation of sensory perception of pain

IGI

1 reference

8 April 2019

Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8MUJ1

Tumour necrosis factor domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8MUJ1

Tumour necrosis factor, conserved site

1 reference

stated in

InterPro Release 71.0