(Q29813543)

English

Rab11 Dmel_CG5771

Protein found in Drosophila melanogaster

Rab11-PA
Rab-protein 11
CG5771 gene product from transcript CG5771-RA
CG5771-PB
lethal(3)93Bi
Rab11-PB
Rab11
CG5771-PA

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O18335

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O18335

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

GTPase activity

determination method

4 references

1 January 2018

Membrane traffic between genomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

Small GTPases and the evolution of the eukaryotic cell

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

protein binding

determination method

5 references

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

protein-containing complex binding

determination method

GTPase activity

determination method

5 references

8 April 2019

Membrane traffic between genomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Small GTPases and the evolution of the eukaryotic cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

nuclear envelope

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

3 references

8 April 2019

Rab11 is required during Drosophila eye development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

1 January 2018

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

8 April 2019

Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

8 April 2019

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

plasma membrane

determination method

1 reference

1 January 2018

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

trans-Golgi network transport vesicle

determination method

1 reference

8 April 2019

Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

4 references

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

The Drosophila Dead end Arf-like3 GTPase controls vesicle trafficking during tracheal fusion cell morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

cleavage furrow

determination method

3 references

8 April 2019

TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

neuronal cell body

determination method

1 reference

1 January 2018

Systematic discovery of Rab GTPases with synaptic functions in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

terminal bouton

determination method

1 reference

8 April 2019

Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

recycling endosome

determination method

4 references

1 January 2018

Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

1 January 2018

Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

plasma membrane

determination method

1 reference

8 April 2019

Mapping organelle proteins and protein complexes in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

dense core granule membrane

determination method

1 reference

8 April 2019

Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Systematic discovery of Rab GTPases with synaptic functions in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

recycling endosome

determination method

5 references

8 April 2019

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

biological process

actomyosin contractile ring contraction

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

compound eye morphogenesis

determination method

1 reference

8 April 2019

Rab11 is required during Drosophila eye development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

male meiosis cytokinesis

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

germarium-derived egg chamber formation

determination method

1 reference

1 January 2018

A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

border follicle cell migration

determination method

3 references

8 April 2019

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

8 April 2019

The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

regulation of pole plasm oskar mRNA localization

determination method

cellularization

determination method

1 reference

8 April 2019

Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

8 April 2019

Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

dorsal closure, elongation of leading edge cells

determination method

1 reference

8 April 2019

Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

oocyte microtubule cytoskeleton polarization

determination method

1 reference

8 April 2019

Rab11 polarization of the Drosophila oocyte: a novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

sensory organ precursor cell fate determination

determination method

1 reference

8 April 2019

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

antimicrobial humoral response

determination method

1 reference

8 April 2019

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

chaeta development

determination method

1 reference

8 April 2019

Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

ovarian follicle cell development

determination method

1 reference

8 April 2019

A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

germ-line stem cell population maintenance

determination method

1 reference

8 April 2019

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

ovarian fusome organization

determination method

1 reference

8 April 2019

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

cortical actin cytoskeleton organization

determination method

1 reference

8 April 2019

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

actin cytoskeleton reorganization

determination method

1 reference

8 April 2019

Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

endocytic recycling

determination method

1 reference

8 April 2019

Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

Rab protein signal transduction

determination method

1 reference

1 January 2018

Evi5 promotes collective cell migration through its Rab-GAP activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

adherens junction maintenance

determination method

1 reference

8 April 2019

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

rhabdomere development

determination method

1 reference

8 April 2019

Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

germ-line stem cell division

determination method

1 reference

8 April 2019

New components of the Drosophila fusome suggest it plays novel roles in signaling and transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

positive regulation of Golgi to plasma membrane protein transport

determination method

1 reference

8 April 2019

Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

fusome organization

determination method

1 reference

8 April 2019

New components of the Drosophila fusome suggest it plays novel roles in signaling and transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

negative regulation of synaptic assembly at neuromuscular junction

determination method

1 reference

8 April 2019

dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

dorsal closure, amnioserosa morphology change

determination method

1 reference

8 April 2019

Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

spermatocyte division

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

Golgi vesicle fusion to target membrane

determination method

1 reference

8 April 2019

Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

1 January 2018

Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

oocyte development

determination method

1 reference

8 April 2019

Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

compound eye development

determination method

1 reference

8 April 2019

Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

regulation of synapse organization

determination method

1 reference

8 April 2019

Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

centrosome localization

determination method

1 reference

8 April 2019

Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

epithelium development

determination method

1 reference

1 January 2018

A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18335&geneProductId=UniProtKB:O18335

determination method

exosomal secretion

determination method

1 reference

8 April 2019

BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

synaptic vesicle endocytosis

determination method

1 reference

8 April 2019

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

protein localization to membrane

determination method

1 reference

8 April 2019

Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18335

determination method

small GTP-binding protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O18335

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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