(Q47733442)

5 February 2018

title

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila. (English)

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5 February 2018

main subject

Rab5 Dmel_CG3664

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GOA release 2020-03-11

Rab11 Dmel_CG5771

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GOA release 2020-03-11

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8

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5 February 2018

Nobutaka Hattori

11

object named as

Nobutaka Hattori

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5 February 2018

Tsuyoshi Inoshita

1

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5 February 2018

Taku Arano

2

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5 February 2018

Yuka Hosaka

3

1 reference

5 February 2018

Hongrui Meng

4

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5 February 2018

Yujiro Umezaki

5

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5 February 2018

Sakiko Kosugi

6

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5 February 2018

Takako Morimoto

7

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5 February 2018

Hui-Yun Chang

9

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5 February 2018

Yuzuru Imai

10

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5 February 2018

publication date

8 May 2017

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5 February 2018

published in

Human Molecular Genetics

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5 February 2018

volume

26

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5 February 2018

issue

15

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5 February 2018

page(s)

2933-2948

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5 February 2018

VPS35 mutations in Parkinson disease

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Functional architecture of the retromer cargo-recognition complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

A FAM21-containing WASH complex regulates retromer-dependent sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

An essential role of Rab5 in uniformity of synaptic vesicle size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Identification of a dopamine pathway that regulates sleep and arousal in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Distinct yet overlapping roles of Rab GTPases on synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Clathrin regenerates synaptic vesicles from endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Ultrafast endocytosis at mouse hippocampal synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Identification of TMEM230 mutations in familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Gradient formation of the TGF-beta homolog Dpp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX179

21 January 2018

Identifiers

DOI

10.1093/HMG/DDX179

1 reference

5 February 2018

PubMed ID

28482024

1 reference

5 February 2018