(Q29817020)

English

Downstream of receptor kinase Dmel_CG6033

Protein found in Drosophila melanogaster

drk-PC
drk
drk-PB
downstream of receptor kinases
CG6033-PB
CG6033-PA
drk-PD
enhancer of sevenless-2B
downstream receptor kinase
downstream of receptor kinase
CG6033-PF
drk-PA
CG6033-PC
CG6033 gene product from transcript CG6033-RF
CG6033-PD
drk-PF

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Statements

1 reference

25 May 2022

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

6 references

9 May 2019

Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

Drosophila activated Cdc42 kinase has an anti-apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IPI

phosphotyrosine residue binding

1 reference

9 May 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

8 April 2019

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IEA

protein-containing complex

1 reference

9 May 2019

Drosophila activated Cdc42 kinase has an anti-apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IEA

epidermal growth factor receptor signaling pathway

3 references

9 May 2019

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

tracheal outgrowth, open tracheal system

1 reference

9 May 2019

Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

epithelial cell migration, open tracheal system

1 reference

9 May 2019

Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

R7 cell fate commitment

3 references

9 May 2019

SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IGI

imaginal disc-derived wing morphogenesis

1 reference

9 May 2019

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

9 May 2019

A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

fibroblast growth factor receptor signaling pathway

1 reference

9 May 2019

Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

ovarian follicle cell development

1 reference

9 May 2019

A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

sevenless signaling pathway

5 references

9 May 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IDA

positive regulation of cell size

1 reference

9 May 2019

PDGF/VEGF signaling controls cell size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

positive regulation of receptor-mediated endocytosis

1 reference

9 May 2019

D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IGI

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

positive regulation of TORC1 signaling

1 reference

9 May 2019

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IMP

torso signaling pathway

3 references

9 May 2019

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

9 May 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

determination method

IDA

Ras protein signal transduction

1 reference

9 May 2019

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08012

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08012

SH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q08012

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

(Q29817020)

Downstream of receptor kinase Dmel_CG6033

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