(Q37264981)

English

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

scientific article published on 22 July 2013

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scholarly article

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5 March 2020

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1 (English)

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5 March 2020

0 references

Tsc1 Dmel_CG6147

1 reference

GOA release 2020-03-11

Ras oncogene at 85D Dmel_CG9375

1 reference

GOA release 2020-03-11

Downstream of receptor kinase Dmel_CG6033

1 reference

GOA release 2020-03-11

Target of rapamycin Dmel_CG5092

1 reference

GOA release 2020-03-11

PVR adaptor protein Dmel_CG32406

1 reference

GOA release 2020-03-11

Thor Dmel_CG8846

1 reference

GOA release 2020-03-11

Ribosomal protein S6 kinase Dmel_CG10539

1 reference

GOA release 2020-03-11

Rolled Dmel_CG12559

1 reference

GOA release 2020-03-11

SHC-adaptor protein Dmel_CG3715

1 reference

GOA release 2020-03-11

Proline-rich Akt substrate 40 kDa Dmel_CG46146

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GOA release 2020-03-11

Samuel Peña-Llopis

3

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5 March 2020

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Tram Anh Tran

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5 March 2020

Lisa Kinch

2

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5 March 2020

Lutz Kockel

4

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Nick Grishin

5

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Huaqi Jiang

6

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James Brugarolas

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publication date

22 July 2013

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5 March 2020

Molecular and Cellular Biology

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5 March 2020

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5 March 2020

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5 March 2020

3762-3779

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5 March 2020

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

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6 September 2017

Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor

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Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

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6 September 2017

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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The expanding TOR signaling network

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The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

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6 September 2017

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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6 September 2017

Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

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6 September 2017

PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis

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6 September 2017

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6 September 2017

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster

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6 September 2017

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6 September 2017

Roles of PDGF in animal development

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6 September 2017

The biology of VEGF and its receptors

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6 September 2017

Akt regulates growth by directly phosphorylating Tsc2

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6 September 2017

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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6 September 2017

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6 September 2017

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6 September 2017

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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6 September 2017

Walking the walk: migration and other common themes in blood and vascular development

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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26 June 2018

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3 September 2018

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3 September 2018

Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration

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3 September 2018

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3 September 2018

Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization

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3 September 2018

PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor

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3 September 2018

The two origins of hemocytes in Drosophila.

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3 September 2018

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

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3 September 2018

Developmental control of blood cell migration by the Drosophila VEGF pathway

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3 September 2018

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3 September 2018

Guidance of cell migration by the Drosophila PDGF/VEGF receptor

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3 September 2018

The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3811881

3 September 2018

Vascular endothelial growth factor (VEGF) activates Raf-1, mitogen-activated protein (MAP) kinases, and S6 kinase (p90rsk) in cultured rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23878397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23878397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin up-regulates vascular endothelial growth factor and stabilizes its messengers in endometrial adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23878397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23878397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23878397

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01570-12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23878397%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23878397%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23878397%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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