(Q51235924)

FKBP12-rapamycin binding domain superfamily

1 reference

Tetratricopeptide-like helical domain superfamily

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Armadillo-type fold

1 reference

Serine/threonine-protein kinase TOR

1 reference

Armadillo-like helical

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

PIK-related kinase, FAT family

1 reference

Tetratricopeptide repeat-containing domain, protein family

1 reference

FKBP12-rapamycin binding domain, protein family

1 reference

PIK-related kinase family

1 reference

FATC domain, protein family

1 reference

Domain of unknown function DUF3385, target of rapamycin protein family

1 reference

Tetratricopeptide repeat family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

Protein kinases and phosphatases in the Drosophila genome

protein kinase activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

protein serine/threonine kinase activity

NAS

1 reference

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

Drosophila target of rapamycin kinase functions as a multimer.

protein self-association

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

protein serine/threonine kinase activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

RNA polymerase III limits longevity downstream of TORC1.

IBA

chromatin DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

A genome-wide resource for the analysis of protein localisation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

regulation of cell growth

HDA

biological process

1 reference

8 April 2019

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of protein phosphorylation

1 reference

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

IBA

protein phosphorylation

1 reference

8 April 2019

1 reference

8 April 2019

Distinct requirements of Autophagy-related genes in programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

regulation of mitotic cell cycle

1 reference

8 April 2019

Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

terminal branching, open tracheal system

1 reference

8 April 2019

Compensatory branching morphogenesis of stalk cells in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

somatic muscle development

1 reference

8 April 2019

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

determination of adult lifespan

TAS

1 reference

8 April 2019

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

negative regulation of macroautophagy

1 reference

24 April 2018

Role and regulation of starvation-induced autophagy in the Drosophila fat body

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

cellular response to nutrient

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

larval midgut cell programmed cell death

1 reference

8 April 2019

Distinct requirements of Autophagy-related genes in programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

multicellular organism growth

1 reference

8 April 2019

Drosophila target of rapamycin kinase functions as a multimer.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

24 April 2018

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VK45&geneProductId=UniProtKB:Q9VK45

positive regulation of multicellular organism growth

1 reference

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

apical protein localization

TAS

1 reference

8 April 2019

Compensatory branching morphogenesis of stalk cells in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of cell size

6 references

8 April 2019

Tor signalling in bugs, brain and brawn

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

PDGF/VEGF signaling controls cell size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of synaptic assembly at neuromuscular junction

1 reference

8 April 2019

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

germarium-derived cystoblast division

1 reference

8 April 2019

TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

dendrite morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of protein kinase B signaling

3 references

8 April 2019

Insulin delays the progression of Drosophila cells through G2/M by activating the dTOR/dRaptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

8 April 2019

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of ribosome biogenesis

1 reference

8 April 2019

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

negative regulation of proteasomal protein catabolic process

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of axon guidance

1 reference

8 April 2019

Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of cell cycle G1/S phase transition

1 reference

8 April 2019

Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

regulation of terminal button organization

1 reference

8 April 2019

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

regulation of response to drug

1 reference

8 April 2019

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

negative regulation of autophagy

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

lamellocyte differentiation

1 reference

8 April 2019

Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

negative regulation of apoptotic process

1 reference

8 April 2019

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

positive regulation of transcription by RNA polymerase III

1 reference

8 April 2019

RNA polymerase III limits longevity downstream of TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

germline cell cycle switching, mitotic to meiotic cell cycle

1 reference

8 April 2019

TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VK45

has part(s)

PIK-related kinase, FAT

1 reference

FKBP12-rapamycin binding domain

1 reference

FATC domain

1 reference

Domain of unknown function DUF3385, target of rapamycin protein

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

Tetratricopeptide repeat-containing domain

1 reference

PIK-related kinase

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

tetratricopeptide repeat

1 reference