(Q34032753)

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Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

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13 February 2020

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo (English)

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13 February 2020

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Phosphatidylinositol 3-kinase 92E Dmel_CG4141

1 reference

GOA release 2020-03-11

Myc Dmel_CG10798

1 reference

GOA release 2020-03-11

Ras homolog enriched in brain Dmel_CG1081

1 reference

GOA release 2020-03-11

Shaggy Dmel_CG2621

1 reference

GOA release 2020-03-11

Target of rapamycin Dmel_CG5092

1 reference

GOA release 2020-03-11

Ribosomal protein S6 kinase Dmel_CG10539

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

4

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13 February 2020

Annalisa Pession

6

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13 February 2020

Daniela Grifoni

7

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13 February 2020

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13 February 2020

author name string

Federica Parisi

1

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13 February 2020

Sara Riccardo

2

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13 February 2020

Margaret Daniel

3

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13 February 2020

Nandini Kundu

5

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13 February 2020

Hugo Stocker

8

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13 February 2020

Esteban Tabak

9

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13 February 2020

publication date

27 September 2011

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13 February 2020

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13 February 2020

9

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13 February 2020

65

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13 February 2020

https://scigraph.springernature.com/pub.10.1186/1741-7007-9-65

0 references

Myc Function in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Regulation of protein stability by GSK3 mediated phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Insulin/TOR signaling in growth and homeostasis: a view from the fly world

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Regulation of TORC1 by Rag GTPases in nutrient response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

mTOR, translation initiation and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Regulation of cell proliferation by a morphogen gradient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Signaling by target of rapamycin proteins in cell growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

dMyc is required for larval growth and endoreplication in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Accumulation of Armadillo induced by Wingless, Dishevelled, and dominant-negative Zeste-White 3 leads to elevated DE-cadherin in Drosophila clone 8 wing disc cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Myc and Max homologs in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Ectopic expression in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Site-specific recombination between homologous chromosomes in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

5 July 2018

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Drosophila myc regulates cellular growth during development.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Drosophila S6 kinase: a regulator of cell size.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

Insulin-like growth factor I induction of c-myc expression in bovine fibroblasts can be blocked by antecedent insulin receptor activation

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo.

1 reference

https://api.crossref.org/works/10.1186%2F1741-7007-9-65

21 January 2018

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235970

29 October 2018

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10.1186/1741-7007-9-65

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Europe PubMed Central

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13 February 2020

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13 February 2020

1 reference

Europe PubMed Central

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13 February 2020

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