(Q27673353)

1

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Brion William Murray

2

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Jeffrey H Chen

3

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Ya-Li Deng

4

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James Solowiej

5

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Robert S Kania

Proceedings of the National Academy of Sciences of the United States of America

6

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language of work or name

English

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publication date

6 November 2012

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published in

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volume

109

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issue

45

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page(s)

18281-9

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cites work

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

1 reference

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Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation

20 March 2017

1 reference

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The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain

20 March 2017

1 reference

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

20 March 2017

1 reference

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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20 March 2017

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A quantitative analysis of kinase inhibitor selectivity

22 April 2017

1 reference

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Data processing and analysis with the autoPROC toolbox

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Comprehensive analysis of kinase inhibitor selectivity

20 March 2017

1 reference

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Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial

7 April 2017

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

7 April 2017

1 reference

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Targeting the unactivated conformations of protein kinases for small molecule drug discovery

7 April 2017

1 reference

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Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial.

29 September 2017

1 reference

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Targeted therapy for advanced renal cell cancer (RCC): a Cochrane systematic review of published randomised trials

29 September 2017

1 reference

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Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety

29 September 2017

1 reference

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Vascular endothelial growth factor-targeted therapies in advanced renal cell carcinoma

29 September 2017

1 reference

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

29 September 2017

1 reference

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The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

29 September 2017

1 reference

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Lessons learned from candidate drug attrition.

29 September 2017

1 reference

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Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry

29 September 2017

1 reference

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Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Characterizing the effects of the juxtamembrane domain on vascular endothelial growth factor receptor-2 enzymatic activity, autophosphorylation, and inhibition by axitinib.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Physicochemical drug properties associated with in vivo toxicological outcomes: a review

29 September 2017

1 reference

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The molecular basis of class side effects due to treatment with inhibitors of the VEGF/VEGFR pathway

29 September 2017

1 reference

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Sunitinib efficacy against advanced renal cell carcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

A comparison of physiochemical property profiles of development and marketed oral drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

High-throughput biochemical kinase selectivity assays: panel development and screening applications.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Immobilized metal ion affinity-based fluorescence polarization (IMAP): advances in kinase screening

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Determination of accurate KI values for tight-binding enzyme inhibitors: an in silico study of experimental error and assay design

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494931

Diastolic blood pressure as a biomarker of axitinib efficacy in solid tumors

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22988103

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1207759109

1 reference

ADS bibcode

2012PNAS..10918281M

0 references

1 reference

1 reference

PubMed publication ID

22988103

1 reference