(Q27643077)

GOA release 2020-03-11

protein self-association

1 reference

GOA release 2020-03-11

author name string

James Griffith

1

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James Black

2

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Carlos Faerman

3

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Lora Swenson

4

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Michael Wynn

5

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Fan Lu

6

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Judith Lippke

7

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Kumkum Saxena

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

8

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publication date

30 January 2004

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published in

Molecular Cell

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volume

13

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page(s)

169-78

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issue

2

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

The roles of FLT3 in hematopoiesis and leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Dimerization of cell surface receptors in signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

The conformational plasticity of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Flt3 mutations and leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Biology and potential clinical applications of flt3 ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Structure of a c-kit product complex reveals the basis for kinase transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

AMoRe: an automated package for molecular replacement

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Signal transduction. Autoinhibition control

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

The role of FLT3 in haematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021

Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900505-7

7 January 2021