(Q44068434)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12124172%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML) (English)

1 reference

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11 November 2019

1 reference

ChEBI release 2020-05-28

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7

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11 November 2019

author name string

Louise M Kelly

1

1 reference

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11 November 2019

Jin-Chen Yu

2

1 reference

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11 November 2019

Christina L Boulton

3

1 reference

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11 November 2019

Mutiah Apatira

4

1 reference

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11 November 2019

Jason Li

5

1 reference

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11 November 2019

Carol M Sullivan

6

1 reference

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11 November 2019

Sonia M Amaral

8

1 reference

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11 November 2019

David P Curley

9

1 reference

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11 November 2019

Nicole Duclos

10

1 reference

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11 November 2019

Donna Neuberg

11

1 reference

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11 November 2019

Robert M Scarborough

12

1 reference

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11 November 2019

Anjali Pandey

13

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11 November 2019

Stanley Hollenbach

14

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11 November 2019

Keith Abe

15

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11 November 2019

Nathalie A Lokker

16

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11 November 2019

D Gary Gilliland

17

1 reference

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11 November 2019

Neill A Giese

18

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11 November 2019

publication date

1 June 2002

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11 November 2019

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11 November 2019

volume

1

1 reference

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11 November 2019

page(s)

421-432

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11 November 2019

issue

5

1 reference

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FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

11 November 2019

cites work

1 reference

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7 January 2021

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

1 reference

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7 January 2021

Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival

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7 January 2021

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.

1 reference

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7 January 2021

Oncogenic kinase signalling

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7 January 2021

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

1 reference

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7 January 2021

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

1 reference

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7 January 2021

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

1 reference

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7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

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7 January 2021

Mechanism of action and in vivo role of platelet-derived growth factor

1 reference

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7 January 2021

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

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7 January 2021

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

1 reference

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7 January 2021

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

1 reference

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7 January 2021

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

1 reference

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7 January 2021

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7 January 2021

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

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7 January 2021

Acute myeloid leukemia

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7 January 2021

SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor

1 reference

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7 January 2021

Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).

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7 January 2021

STI571: targeting BCR-ABL as therapy for CML.

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7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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7 January 2021

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

1 reference

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7 January 2021

Imatinib mesylate--a new oral targeted therapy

1 reference

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7 January 2021

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1 reference

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7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

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7 January 2021

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

1 reference

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7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

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7 January 2021

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

1 reference

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7 January 2021

AKT plays a central role in tumorigenesis

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7 January 2021

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1 reference

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7 January 2021

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

1 reference

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7 January 2021

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

1 reference

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7 January 2021

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1 reference

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7 January 2021

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

1 reference

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7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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7 January 2021

10.1016/S1535-6108(02)00070-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12124172%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference